Difference between revisions of "Eosinophilic, solid and cystic renal cell carcinoma"

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'''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is an evolving [[kidney tumour]] that is presumed to be malignant.<ref name=pmid26414221>{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref>
'''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is recently described, evolving [[kidney tumour]] that is presumed to be [[malignant]].<ref name=pmid26414221>{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref>


It is not within the ''[[Vancouver classification]]'' of [[renal tumours]].<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>
It is ''not'' within the [[Vancouver classification]] of [[renal tumours]].<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>


==General==
==General==

Revision as of 04:35, 7 November 2015

Eosinophilic, solid and cystic renal cell carcinoma
Diagnosis in short
Stains PAX8 +ve, CK20 +ve, CD117 -ve
Gross solid and cystic
Site kidney - see kidney tumours
Clinical history women only
Prevalence rare
Prognosis good - data limited
Clin. DDx other kidney tumours

Eosinophilic, solid and cystic renal cell carcinoma, abbreviated ESC-RCC, is recently described, evolving kidney tumour that is presumed to be malignant.[1]

It is not within the Vancouver classification of renal tumours.[2]

General

Gross

Features:[1]

  • Tan colour.
  • Solid and usually cystic.

Microscopic

Features:[1]

  • Epithelioid cells with abundant stippled eosinophilic cytoplasm +/- peripheral clearing.
  • Round nuclei with prominent (ISUP nucleolar grade 3) nucleoli (seen with 10x objective).
  • Nested or solid architecture +/- cystic spaces with hobnail lining cells.
  • +/-Scattered histiocytes (common).
  • +/-Multi-nucleation (common).
  • +/-Small intracytoplasmic globules - usually seen but only present in a handful of cells.

DDx:

IHC

Features:[1]

  • PAX8 +ve.
  • CK20 +ve.
  • CK7 -ve.
  • CD117 -ve.
  • CA9 -ve.
  • HMB-45 -ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Trpkov, K.; Hes, O.; Bonert, M.; Lopez, JI.; Bonsib, SM.; Nesi, G.; Comperat, E.; Sibony, M. et al. (Sep 2015). "Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women.". Am J Surg Pathol. doi:10.1097/PAS.0000000000000508. PMID 26414221.
  2. ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
  3. ↑ Guo, J.; Tretiakova, MS.; Troxell, ML.; Osunkoya, AO.; Fadare, O.; Sangoi, AR.; Shen, SS.; Lopez-Beltran, A. et al. (Nov 2014). "Tuberous Sclerosis-associated Renal Cell Carcinoma: A Clinicopathologic Study of 57 Separate Carcinomas in 18 Patients.". Am J Surg Pathol 38 (11): 1457-67. doi:10.1097/PAS.0000000000000248. PMID 25093518.
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