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| Caption = High-grade prostatic intraepithelial neoplasia. [[H&E stain]]. | | Caption = High-grade prostatic intraepithelial neoplasia. [[H&E stain]]. | ||
| Synonyms = prostatic intraepithelial neoplasia | | Synonyms = prostatic intraepithelial neoplasia | ||
| Micro = nuclear changes (hyperchromatic nuclei, nucleoli present, +/-increased NC ratio, mild-to-moderate nuclear enlargement), medium-to-large glands with the architecture of HGPIN (tufted, micropapillary, cribriform, flat) | | Micro = nuclear changes (hyperchromatic nuclei, nucleoli present, +/-increased NC ratio, mild-to-moderate nuclear enlargement), medium-to-large glands with the architecture of HGPIN (tufted, micropapillary, [[cribriform]], flat) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[basal cell hyperplasia]], [[prostatic adenocarcinoma]], [[PIN-like prostatic ductal adenocarcinoma]], [[atypical small acinar proliferation]] (biopsy only) | | LMDDx = [[basal cell hyperplasia]], [[prostatic adenocarcinoma]], [[PIN-like prostatic ductal adenocarcinoma]], [[atypical small acinar proliferation]] (biopsy only) | ||
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*Tufting - common. | *Tufting - common. | ||
*Micropapillary - common. | *Micropapillary - common. | ||
*Cribriform - rare. | *[[Cribriform]] - rare. | ||
Note: | Note: |
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