Difference between revisions of "Atypical adenomatous hyperplasia of the lung"

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Features:<ref name=Ref_WMSP114>{{Ref WMSP|114}}</ref>
Features:<ref name=Ref_WMSP114>{{Ref WMSP|114}}</ref>
*Enlarged alveolar lining cells with:
*Enlarged alveolar lining cells with:
**Hobnail morphology - free (luminal) surface area > attached/basal surface area.
**[[Hobnail morphology]] - free (luminal) surface area > attached/basal surface area.
**Round or oval nuclei.<ref name=pmid21252716/>
**Round or oval nuclei.<ref name=pmid21252716/>
***Nuclear hyperchromasia.
***Nuclear hyperchromasia.

Revision as of 03:03, 31 October 2015

Atypical alveolar hyperplasia of the lung, also atypical adenomatous hyperplasia (abbreviated AAH) and atypical alveolar hyperplasia, is considered the precursor of lung adenocarcinoma. It is typically found beside lung adenocarcinoma in resection specimens.[1]

General

  • Generally considered the precursor lesion to adenocarcinoma in situ.[2]
  • Typically an incidental finding, i.e. asymptomatic.[3]

Microscopic

Features:[3]

  • Enlarged alveolar lining cells with:
    • Hobnail morphology - free (luminal) surface area > attached/basal surface area.
    • Round or oval nuclei.[1]
      • Nuclear hyperchromasia.
      • +/-Nuclear enlargement (mild-to-moderate).
      • +/-Multinucleation.
  • Spaces are typically seen between the cells[1] - important.
  • Limited extent:
    • <5 mm. †

DDx:

Note:

Images

See also

References

  1. ↑ 1.0 1.1 1.2 Travis, WD.; Brambilla, E.; Noguchi, M.; Nicholson, AG.; Geisinger, KR.; Yatabe, Y.; Beer, DG.; Powell, CA. et al. (Feb 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.". J Thorac Oncol 6 (2): 244-85. doi:10.1097/JTO.0b013e318206a221. PMID 21252716.
  2. ↑ 2.0 2.1 Sakuma, Y.; Matsukuma, S.; Yoshihara, M.; Nakamura, Y.; Nakayama, H.; Kameda, Y.; Tsuchiya, E.; Miyagi, Y. (Sep 2007). "Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung.". Mod Pathol 20 (9): 967-73. doi:10.1038/modpathol.3800929. PMID 17618248.
  3. ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 114. ISBN 978-0781765275.
  4. ↑ Davidson, MR.; Gazdar, AF.; Clarke, BE. (Oct 2013). "The pivotal role of pathology in the management of lung cancer.". J Thorac Dis 5 (Suppl 5): S463-S478. doi:10.3978/j.issn.2072-1439.2013.08.43. PMID 24163740.
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