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Difference between revisions of "Graves' disease"
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'''Graves' disease''', also '''Graves disease''', is an [[autoimmune disease]] that leads to hyperthyroidism. | |||
==General== | |||
*Often misspelled "Grave's disease". | |||
*Autoimmune disease leading to hyperthyroidism. | |||
*Eye problems not resolved with thyroid removal.{{fact}} | |||
*Higher risk of [[papillary thyroid carcinoma]]. | |||
Clinical: | |||
*TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal | last1 = Massart | first1 = C. | last2 = Gibassier | first2 = J. | last3 = d'Herbomez | first3 = M. | title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. | journal = Clin Chim Acta | volume = 407 | issue = 1-2 | pages = 62-6 | month = Sep | year = 2009 | doi = 10.1016/j.cca.2009.06.033 | PMID = 19576193 }}</ref> | |||
==Gross== | |||
Features:<ref>{{Ref EP|30}}</ref> | |||
*Enlarged 50-150 g. | |||
*"Beefy-red" appearance, looks like raw beef. | |||
==Microscopic== | |||
Features: | |||
*Classic: | |||
**Hypercellular | |||
**Patchy lymphocytes. | |||
**Little colloid. | |||
*Scalloping of colloid; colloid has undulating border. | |||
**Non-specific finding. | |||
*+/-Nuclear clearing. | |||
*+/-Papillae (may mimic papillary thyroid carcinoma in this respect). | |||
Notes: | |||
*Usually has an unimpressive appearance... as it is treated, i.e. history is important. | |||
*Nuclear clearing and papillae are usu. diffuse in Graves disease - unlike in papillary thyroid carcinoma. | |||
===Images=== | |||
www: | |||
*[http://library.med.utah.edu/WebPath/jpeg4/ENDO022.jpg Graves disease (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html]. Accessed on: 4 December 2011.</ref> | |||
*[http://medcell.med.yale.edu/histology/endocrine_systems_lab/graves_disease.php Graves disease & normal thyroid (yale.edu)]. | |||
==See also== | |||
*[[Thyroid gland]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Thyroid gland]] | |||
[[Category:Diagnosis]] | |||