Difference between revisions of "Papillary urothelial neoplasm of low malignant potential"

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*Nuclei larger than papilloma - but monotonous.<ref name=Ref_GUP170>{{Ref GUP|170}}</ref>
*Nuclei larger than papilloma - but monotonous.<ref name=Ref_GUP170>{{Ref GUP|170}}</ref>


Note:
*May grow downward; known as ''PUNLMP with inverted growth''.<ref name=pmid25886613>{{Cite journal  | last1 = Maxwell | first1 = JP. | last2 = Wang | first2 = C. | last3 = Wiebe | first3 = N. | last4 = Yilmaz | first4 = A. | last5 = Trpkov | first5 = K. | title = Long-term outcome of primary Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) including PUNLMP with inverted growth. | journal = Diagn Pathol | volume = 10 | issue =  | pages = 3 | month =  | year = 2015 | doi = 10.1186/s13000-015-0234-z | PMID = 25886613 }}</ref>
DDx:
DDx:
*[[Low grade papillary urothelial carcinoma]].
*[[Low grade papillary urothelial carcinoma]].

Revision as of 16:04, 21 October 2015

Papillary urothelial neoplasm of low malignant potential
Diagnosis in short

PUNLMP. H&E stain.
LM rare fused papillae, infrequent mitoses, nuclei larger than papilloma - but monotonous
LM DDx low grade papillary urothelial carcinoma, urothelial papilloma
Site urothelium
Prevalence uncommon
Treatment excision and on-going follow-up - like non-invasive low grade papillary urothelial carcinoma

Papillary urothelial neoplasm of low malignant potential, abbreviated PUNLMP, is an uncommon urothelial lesion that is similar to low-grade papillary urothelial carcinoma.

PUNLMP is pronounced pun-lump.

General

Treatment:

Microscopic

Features:[5]

  • Rare fused papillae.
  • Infrequent mitoses.
  • Nuclei larger than papilloma - but monotonous.[6]

Note:

  • May grow downward; known as PUNLMP with inverted growth.[7]

DDx:

Images

  • PUNLMP - low mag. (WC/Nephron)

  • PUNLMP - high mag. (WC/Nephron)

See also

References

  1. ↑ May M, Brookman-Amissah S, Roigas J, et al. (March 2009). "Prognostic Accuracy of Individual Uropathologists in Noninvasive Urinary Bladder Carcinoma: A Multicentre Study Comparing the 1973 and 2004 World Health Organisation Classifications". Eur. Urol. 57 (5): 850. doi:10.1016/j.eururo.2009.03.052. PMID 19346063.
  2. ↑ MacLennan GT, Kirkali Z, Cheng L (April 2007). "Histologic grading of noninvasive papillary urothelial neoplasms". Eur. Urol. 51 (4): 889–97; discussion 897–8. doi:10.1016/j.eururo.2006.10.037. PMID 17095142.
  3. ↑ Jones TD, Cheng L (June 2006). "Papillary urothelial neoplasm of low malignant potential: evolving terminology and concepts". J. Urol. 175 (6): 1995–2003. doi:10.1016/S0022-5347(06)00267-9. PMID 16697785.
  4. ↑ Cheng, L.; Maclennan, GT.; Lopez-Beltran, A. (Dec 2012). "Histologic grading of urothelial carcinoma: a reappraisal.". Hum Pathol 43 (12): 2097-108. doi:10.1016/j.humpath.2012.01.008. PMID 22542126.
  5. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 310. ISBN 978-0781765275.
  6. ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 170. ISBN 978-0443066771.
  7. ↑ Maxwell, JP.; Wang, C.; Wiebe, N.; Yilmaz, A.; Trpkov, K. (2015). "Long-term outcome of primary Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) including PUNLMP with inverted growth.". Diagn Pathol 10: 3. doi:10.1186/s13000-015-0234-z. PMID 25886613.
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