Difference between revisions of "Prostate chips grossing"
| Line 27: | Line 27: | ||
***16 grams: 6-8 cassettes for 12 grams + 1 cassette = 7-9 cassettes. | ***16 grams: 6-8 cassettes for 12 grams + 1 cassette = 7-9 cassettes. | ||
***21 grams: 6-8 cassettes for 12 grams + 2 cassettes = 7-9 cassettes. | ***21 grams: 6-8 cassettes for 12 grams + 2 cassettes = 7-9 cassettes. | ||
<!-- | |||
<math> | |||
N = (m -12)/5 + 8. | |||
</math> | |||
Where: | |||
<br>N = number of blocks. | |||
<br>m = mass of the prostate tissue. | |||
--> | |||
What to look for/feel for:<ref name=Ref_Lester398>{{Ref Lester|398}}</ref> | What to look for/feel for:<ref name=Ref_Lester398>{{Ref Lester|398}}</ref> | ||
Revision as of 15:00, 21 October 2015
This article deals with prostate chips grossing. TURP specimens redirects here.
Introduction
Prostate chips are generated from transurethral resection of the prostate (TURP) procedures. These are generally for relieving urinary obstruction due to nodular hyperplasia of the prostate (benign prostatic hyperplasia); however, urinary obstruction may be secondary to prostate cancer. Thus, the job of the pathologist here, usually, is excluding an incidental cancer.
The prevalence of prostate cancer varies from 7% (in a series 823 TURPs[1]) to 17% (in an older series of 747 TURPs[2]).
Clinically relevant cancer in procedures done for BPH (TURPs and prostatectomies) is seen in approximately 1.5% of specimens.[1]
Protocol
Specimen:
- Weight ___ grams.
- Dimensions (in aggregate): ___ x ___ x ___ cm.
- Number of fragments: [1-6 / multiple (>6)].
- Appearance: [tan-gray / yellow / orange].
- Consistency: [rubbery / firm].
- Other: [none / hemorrhagic appearance / necrotic appearing].
[Submitted in total/Representative sections submitted] in block(s) ___.
Protocol notes
Number of cassettes:[3]
- <= 12 grams: EIT.
- >12 grams: embed 12 grams and 1 cassette for every additional 5 grams.
- If the prostate chips have a mass of:
- 16 grams: 6-8 cassettes for 12 grams + 1 cassette = 7-9 cassettes.
- 21 grams: 6-8 cassettes for 12 grams + 2 cassettes = 7-9 cassettes.
- If the prostate chips have a mass of:
What to look for/feel for:[3]
| Entity | Colour | Firmness |
|---|---|---|
| Prostate cancer | yellow/orange | firm |
| Benign prostate | tan/gray | rubbery |
Alternate approaches
See also
Related protocols
References
- ↑ 1.0 1.1 Skrzypczyk, MA.; Dobruch, J.; Nyk, L.; Szostek, P.; Szempliński, S.; Borówka, A. (2014). "Should all specimens taken during surgical treatment of patients with benign prostatic hyperplasia be assessed by a pathologist?". Cent European J Urol 67 (3): 227-32. doi:10.5173/ceju.2014.03.art2. PMID 25247076.
- ↑ Trpkov, K.; Thompson, J.; Kulaga, A.; Yilmaz, A. (Aug 2008). "How much tissue sampling is required when unsuspected minimal prostate carcinoma is identified on transurethral resection?". Arch Pathol Lab Med 132 (8): 1313-6. doi:10.1043/1543-2165(2008)132[1313:HMTSIR]2.0.CO;2. PMID 18684032.
- ↑ 3.0 3.1 Lester, Susan Carole (2005). Manual of Surgical Pathology (2nd ed.). Saunders. pp. 398. ISBN 978-0443066450.