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Difference between revisions of "Nucleolus"
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→Indistinct nucleolus
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[[Image:Epithelioid_sarcoma_-_cropped_-_very_high_mag.jpg|thumb|right|[[Micrograph]] showing a tumour (epithelioid sarcoma) with prominent nucleoli. [[H&E stain]].]] | |||
The '''nucleolus''' (plural '''nucleoli''') is a thingy in the nucleus that may give the pathologist a clue to what they are looking at. | The '''nucleolus''' (plural '''nucleoli''') is a thingy in the nucleus that may give the pathologist a clue to what they are looking at. | ||
Generally speaking, large nucleoli | Generally speaking, large nucleoli suggest something is happening - they are associated with gene transcription. Large nucleoli are seen in malignancies and reactive conditions. | ||
==Macronucleolus== | ==Macronucleolus== | ||
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Example: | Example: | ||
*Reed-Sternberg cell ([[Hodgkin lymphoma]]) ~ 5-7 micrometers.<ref name=Ref_PCPBoD8_329>{{Ref PCPBoD8|329}}</ref> | *Reed-Sternberg cell ([[Hodgkin lymphoma]]) ~ 5-7 micrometers.<ref name=Ref_PCPBoD8_329>{{Ref PCPBoD8|329}}</ref> | ||
===Image=== | |||
<gallery> | |||
Image:Glioblastoma_with_extreme_nuclear_enlargement_-_very_high_mag.jpg | Extreme nuclear enlargement with huge macronucleoli. (WC) | |||
</gallery> | |||
==Red nucleolus== | ==Red nucleolus== | ||
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*[[Melanoma]]. | *[[Melanoma]]. | ||
*[[Serous carcinoma]]. | *[[Serous carcinoma]]. | ||
*[[Hereditary leiomyomatosis and renal cell carcinoma|Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]]. | |||
==Large | ==Large nucleolus== | ||
Large - can be seen with 10x objective. | Large - can be seen with 10x objective. | ||
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**[[Atypical teratoid/rhabdoid tumour]]. | **[[Atypical teratoid/rhabdoid tumour]]. | ||
**Epithelioid [[angiosarcoma]]. | **Epithelioid [[angiosarcoma]]. | ||
*[[Ganglion cell]]: | |||
**Ganglion (benign). | |||
**[[Gangliocytic paraganglioma]]. | |||
**[[Ganglioneuroma]]. | |||
==Medium-sized nucleolus== | ==Medium-sized nucleolus== | ||
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Examples: | Examples: | ||
*Prostatic | *[[Prostatic adenocarcinoma]]. | ||
*Oncocytoma. | *[[Oncocytoma]]. | ||
*Mammary carcinoma, no special type. | *[[Invasive ductal carcinoma of the breast|Mammary carcinoma, no special type]]. | ||
*[[ | *[[Embryonal carcinoma]]. | ||
*[[Squamous metaplasia of the uterine cervix]]. | |||
==Small== | ==Small== | ||
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Examples: | Examples: | ||
*[[Small cell carcinoma]]. | *[[Small cell carcinoma]]. | ||
*[[Neuroendocrine carcinoma]]. | |||
==See also== | ==See also== | ||
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{{Reflist|1}} | {{Reflist|1}} | ||
[[Category: | [[Category:Histology]] | ||