48,584
edits
Difference between revisions of "Phosphaturic mesenchymal tumour, mixed connective tissue type"
Jump to navigation
Jump to search
Phosphaturic mesenchymal tumour, mixed connective tissue type (view source)
Revision as of 23:13, 2 October 2015
, 23:13, 2 October 2015no edit summary
(→IHC) |
|||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Phosphaturic mesenchymal tumour -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Phosphaturic mesenchymal tumour, mixed connective tissue type. [[H&E stain]]. | ||
| Micro = spindle cells without atypia | | Micro = spindle cells without atypia | ||
| Subtypes = | | Subtypes = | ||
| Line 60: | Line 60: | ||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Phosphaturic mesenchymal tumour -- intermed mag.jpg | PMTMCT - intermed. mag. (WC) | |||
Image: Phosphaturic mesenchymal tumour -- high mag.jpg | PMTMCT - high mag. (WC) | |||
Image: Phosphaturic mesenchymal tumour - alt -- high mag.jpg | PMTMCT - high mag. (WC) | |||
Image: Phosphaturic mesenchymal tumour -- very high mag.jpg | PMTMCT - very high mag. (WC) | |||
Image: Phosphaturic mesenchymal tumour - alt -- very high mag.jpg | PMTMCT - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783479/figure/F4/ PMTMCT (nih.gov)].<ref name=pmid19828339>{{Cite journal | last1 = Woo | first1 = VL. | last2 = Landesberg | first2 = R. | last3 = Imel | first3 = EA. | last4 = Singer | first4 = SR. | last5 = Folpe | first5 = AL. | last6 = Econs | first6 = MJ. | last7 = Kim | first7 = T. | last8 = Harik | first8 = LR. | last9 = Jacobs | first9 = TP. | title = Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 108 | issue = 6 | pages = 925-32 | month = Dec | year = 2009 | doi = 10.1016/j.tripleo.2009.07.005 | PMID = 19828339 | PMC = 2783479 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783479/figure/F4/ PMTMCT (nih.gov)].<ref name=pmid19828339>{{Cite journal | last1 = Woo | first1 = VL. | last2 = Landesberg | first2 = R. | last3 = Imel | first3 = EA. | last4 = Singer | first4 = SR. | last5 = Folpe | first5 = AL. | last6 = Econs | first6 = MJ. | last7 = Kim | first7 = T. | last8 = Harik | first8 = LR. | last9 = Jacobs | first9 = TP. | title = Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 108 | issue = 6 | pages = 925-32 | month = Dec | year = 2009 | doi = 10.1016/j.tripleo.2009.07.005 | PMID = 19828339 | PMC = 2783479 }}</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013303/figure/cjc-30-11-794-g003/ PMTMCT (nih.gov)].<ref name=pmid22035861/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013303/figure/cjc-30-11-794-g003/ PMTMCT (nih.gov)].<ref name=pmid22035861/> | ||
| Line 65: | Line 73: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid19828339>{{Cite journal | last1 = Woo | first1 = VL. | last2 = Landesberg | first2 = R. | last3 = Imel | first3 = EA. | last4 = Singer | first4 = SR. | last5 = Folpe | first5 = AL. | last6 = Econs | first6 = MJ. | last7 = Kim | first7 = T. | last8 = Harik | first8 = LR. | last9 = Jacobs | first9 = TP. | title = Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 108 | issue = 6 | pages = 925-32 | month = Dec | year = 2009 | doi = 10.1016/j.tripleo.2009.07.005 | PMID = 19828339 | PMC = 2783479 }}</ref> | Features:<ref name=pmid19828339>{{Cite journal | last1 = Woo | first1 = VL. | last2 = Landesberg | first2 = R. | last3 = Imel | first3 = EA. | last4 = Singer | first4 = SR. | last5 = Folpe | first5 = AL. | last6 = Econs | first6 = MJ. | last7 = Kim | first7 = T. | last8 = Harik | first8 = LR. | last9 = Jacobs | first9 = TP. | title = Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 108 | issue = 6 | pages = 925-32 | month = Dec | year = 2009 | doi = 10.1016/j.tripleo.2009.07.005 | PMID = 19828339 | PMC = 2783479 }}</ref> | ||
*FGF-23 +ve -- key immunostain.<ref name=pmid14707860>{{cite journal |author=Folpe AL, Fanburg-Smith JC, Billings SD, ''et al.'' |title=Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature |journal=Am. J. Surg. Pathol. |volume=28 |issue=1 |pages=1–30 |year=2004 |month=January |pmid=14707860 |doi= |url=}}</ref> | *FGF-23 +ve -- key immunostain (17 +ve/21 cases).<ref name=pmid14707860>{{cite journal |author=Folpe AL, Fanburg-Smith JC, Billings SD, ''et al.'' |title=Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature |journal=Am. J. Surg. Pathol. |volume=28 |issue=1 |pages=1–30 |year=2004 |month=January |pmid=14707860 |doi= |url=}}</ref> | ||
*Vimentin +ve. | *Vimentin +ve. | ||
*Pankeratin -ve. | *Pankeratin -ve. | ||
| Line 74: | Line 82: | ||
*CD68 +ve.(???) | *CD68 +ve.(???) | ||
*Desmin -ve. | *Desmin -ve. | ||
*Actin -ve/+ve (3 +ve/ | *Actin -ve/+ve (3 +ve/21 cases).<ref name=pmid14707860/> | ||
==Sign out== | |||
<pre> | |||
LEFT CALF, BIOPSY: | |||
- SPINDLE CELL LESION WITHOUT SIGNIFICANT NUCLEAR ATYPIA AND SHABBY HYALINE | |||
MATERIAL WITH CALCIFICATIONS, SEE COMMENT. | |||
COMMENT: | |||
The tumour stains as follows: | |||
POSITIVE: vimentin, CD68 (focal). | |||
NEGATIVE: pankeratin, S-100, CD34. | |||
PROLIFERATION (Ki-67): 3% of lesional cells. | |||
This probably represents a recurrence of the "phosphaturic mesenchymal tumour, mixed | |||
connective tissue type". | |||
The case was compared to the previous pathology. Clinical correlation is recommended. | |||
</pre> | |||
==References== | ==References== | ||