Difference between revisions of "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia"
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==General== | ==General== | ||
*Rare. | *Rare - less than 50 reported based on a 2010 paper.<ref name=pmid22798306>{{Cite journal | last1 = Tippett | first1 = VM. | last2 = Wathen | first2 = CG. | title = Diffuse idiopathic neuroendocrine cell hyperplasia: an unusual cause of breathlessness and pulmonary nodules. | journal = BMJ Case Rep | volume = 2010 | issue = | pages = | month = | year = 2010 | doi = 10.1136/bcr.05.2010.3006 | PMID = 22798306 }}</ref> | ||
*Usually women (15 of 19 cases<ref name=pmid17099078>{{Cite journal | last1 = Davies | first1 = SJ. | last2 = Gosney | first2 = JR. | last3 = Hansell | first3 = DM. | last4 = Wells | first4 = AU. | last5 = du Bois | first5 = RM. | last6 = Burke | first6 = MM. | last7 = Sheppard | first7 = MN. | last8 = Nicholson | first8 = AG. | title = Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. | journal = Thorax | volume = 62 | issue = 3 | pages = 248-52 | month = Mar | year = 2007 | doi = 10.1136/thx.2006.063065 | PMID = 17099078 }}</ref>). | *Usually women (15 of 19 cases<ref name=pmid17099078>{{Cite journal | last1 = Davies | first1 = SJ. | last2 = Gosney | first2 = JR. | last3 = Hansell | first3 = DM. | last4 = Wells | first4 = AU. | last5 = du Bois | first5 = RM. | last6 = Burke | first6 = MM. | last7 = Sheppard | first7 = MN. | last8 = Nicholson | first8 = AG. | title = Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. | journal = Thorax | volume = 62 | issue = 3 | pages = 248-52 | month = Mar | year = 2007 | doi = 10.1136/thx.2006.063065 | PMID = 17099078 }}</ref>). | ||
*Typically non-smokers (16 of 19 cases<ref name=pmid17099078/>). | *Typically non-smokers (16 of 19 cases<ref name=pmid17099078/>). | ||
Revision as of 13:30, 25 September 2015
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, abbreviated DIPNECH, is an uncommon lung pathology that is considered pre-neoplastic by the WHO.[1]
General
- Rare - less than 50 reported based on a 2010 paper.[2]
- Usually women (15 of 19 cases[3]).
- Typically non-smokers (16 of 19 cases[3]).
Clinical:[4]
- Typical patient in 60s.
- Cough.
Treatment:
- Somatostatin analogs[4] - improves cough.
Gross
- Multiple small pulmonary nodules.[1]
DDx:
Microscopic
See also
References
- ↑ 1.0 1.1 Wirtschafter, E.; Walts, AE.; Liu, ST.; Marchevsky, AM. (Jun 2015). "Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence.". Lung. doi:10.1007/s00408-015-9755-1. PMID 26104490.
- ↑ Tippett, VM.; Wathen, CG. (2010). "Diffuse idiopathic neuroendocrine cell hyperplasia: an unusual cause of breathlessness and pulmonary nodules.". BMJ Case Rep 2010. doi:10.1136/bcr.05.2010.3006. PMID 22798306.
- ↑ 3.0 3.1 Davies, SJ.; Gosney, JR.; Hansell, DM.; Wells, AU.; du Bois, RM.; Burke, MM.; Sheppard, MN.; Nicholson, AG. (Mar 2007). "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.". Thorax 62 (3): 248-52. doi:10.1136/thx.2006.063065. PMID 17099078.
- ↑ 4.0 4.1 Chauhan, A.; Ramirez, RA. (Jun 2015). "Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series.". Lung. doi:10.1007/s00408-015-9754-2. PMID 26112453.