Difference between revisions of "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia"

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==General==
==General==
*Rare.
*Rare.
*Usually women (15 of 19 cases<ref name=pmid17099078>{{Cite journal  | last1 = Davies | first1 = SJ. | last2 = Gosney | first2 = JR. | last3 = Hansell | first3 = DM. | last4 = Wells | first4 = AU. | last5 = du Bois | first5 = RM. | last6 = Burke | first6 = MM. | last7 = Sheppard | first7 = MN. | last8 = Nicholson | first8 = AG. | title = Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. | journal = Thorax | volume = 62 | issue = 3 | pages = 248-52 | month = Mar | year = 2007 | doi = 10.1136/thx.2006.063065 | PMID = 17099078 }}</ref>).
*Typically non-smokers (16 of 19 cases<ref name=pmid17099078/>).


Clinical:<ref name=pmid26112453>{{Cite journal  | last1 = Chauhan | first1 = A. | last2 = Ramirez | first2 = RA. | title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. | journal = Lung | volume =  | issue =  | pages =  | month = Jun | year = 2015 | doi = 10.1007/s00408-015-9754-2 | PMID = 26112453 }}</ref>
Clinical:<ref name=pmid26112453>{{Cite journal  | last1 = Chauhan | first1 = A. | last2 = Ramirez | first2 = RA. | title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. | journal = Lung | volume =  | issue =  | pages =  | month = Jun | year = 2015 | doi = 10.1007/s00408-015-9754-2 | PMID = 26112453 }}</ref>

Revision as of 13:27, 25 September 2015

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, abbreviated DIPNECH, is an uncommon lung pathology that is considered pre-neoplastic by the WHO.[1]

General

  • Rare.
  • Usually women (15 of 19 cases[2]).
  • Typically non-smokers (16 of 19 cases[2]).

Clinical:[3]

  • Typical patient in 60s.
  • Cough.

Treatment:

  • Somatostatin analogs[3] - improves cough.

Gross

  • Multiple small pulmonary nodules.[1]

DDx:

Microscopic

See typical lung carcinoid tumour

See also

References

  1. 1.0 1.1 Wirtschafter, E.; Walts, AE.; Liu, ST.; Marchevsky, AM. (Jun 2015). "Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence.". Lung. doi:10.1007/s00408-015-9755-1. PMID 26104490.
  2. 2.0 2.1 Davies, SJ.; Gosney, JR.; Hansell, DM.; Wells, AU.; du Bois, RM.; Burke, MM.; Sheppard, MN.; Nicholson, AG. (Mar 2007). "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.". Thorax 62 (3): 248-52. doi:10.1136/thx.2006.063065. PMID 17099078.
  3. 3.0 3.1 Chauhan, A.; Ramirez, RA. (Jun 2015). "Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series.". Lung. doi:10.1007/s00408-015-9754-2. PMID 26112453.