Difference between revisions of "Alpha-methylacyl-CoA racemase"

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[[Image:Atypical_small_acinar_proliferation_-_AMACR-CK34betaE12_-_alt_--_very_high_mag.jpg|thumb|right|AMACR positivity in [[ASAP]]. CK5/6-AMACR immunostain.]]
{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image     = Atypical_small_acinar_proliferation_-_AMACR-CK34betaE12_-_alt_--_very_high_mag.jpg
| Width      =
| Caption    = AMACR positivity in [[ASAP]]. CK5/6-AMACR immunostain
| Abbrev    = AMACR
| Synonyms  = racemase
| Similar    =
| Clones    =     
| Use        =
| Subspecial = [[genitourinary pathology]] 
| Pattern    = cytoplasmic
| Positive  = [[prostate carcinoma]] ~90%, [[high grade prostatic intraepithelial neoplasia]], [[urothelial carcinoma]] ~50%, [[papillary renal cell carcinoma]]
| Negative  = [[clear cell papillary renal cell carcinoma]] (clear cell tubulopapillary RCC)
| Other      =
}}
'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].
'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].



Revision as of 03:04, 22 September 2015

Alpha-methylacyl-CoA racemase
Immunostain in short

AMACR positivity in ASAP. CK5/6-AMACR immunostain
Abbreviation AMACR
Synonyms racemase
Subspeciality genitourinary pathology
Normal staining pattern cytoplasmic
Positive prostate carcinoma ~90%, high grade prostatic intraepithelial neoplasia, urothelial carcinoma ~50%, papillary renal cell carcinoma
Negative clear cell papillary renal cell carcinoma (clear cell tubulopapillary RCC)

Alpha-methylacyl-CoA racemase, abbreviated AMACR, is a commonly used immunostain in genitourinary pathology.

General

AMACR converts testosterone to hydrotestosterone.[1]

Positive

Positive or negative

Negative

See also

References

  1. Cai, LQ.; Zhu, YS.; Katz, MD.; Herrera, C.; Baéz, J.; DeFillo-Ricart, M.; Shackleton, CH.; Imperato-McGinley, J. (May 1996). "5 alpha-reductase-2 gene mutations in the Dominican Republic.". J Clin Endocrinol Metab 81 (5): 1730-5. doi:10.1210/jcem.81.5.8626825. PMID 8626825.
  2. Lloyd, MD.; Yevglevskis, M.; Lee, GL.; Wood, PJ.; Threadgill, MD.; Woodman, TJ. (Apr 2013). "α-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S.". Prog Lipid Res 52 (2): 220-30. doi:10.1016/j.plipres.2013.01.001. PMID 23376124.
  3. Molinié, V.; Balaton, A.; Rotman, S.; Mansouri, D.; De Pinieux, I.; Homsi, T.; Guillou, L. (Jun 2006). "Alpha-methyl CoA racemase expression in renal cell carcinomas.". Hum Pathol 37 (6): 698-703. doi:10.1016/j.humpath.2006.01.012. PMID 16733210.
  4. Langner, C.; Rupar, G.; Leibl, S.; Hutterer, G.; Chromecki, T.; Hoefler, G.; Rehak, P.; Zigeuner, R. (Mar 2006). "Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression.". Virchows Arch 448 (3): 325-30. doi:10.1007/s00428-005-0129-6. PMID 16315020.