Difference between revisions of "Typical carcinoid lung tumour"
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==General== | ==General== | ||
*Approximately 80% of lung carcinoids.<ref name=pmid20888248>{{Cite journal | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref> | *Approximately 80% of lung carcinoids.<ref name=pmid20888248>{{Cite journal | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref> | ||
*May be multiple.<ref name=pmid356600>{{Cite journal | last1 = Miller | first1 = MA. | last2 = Mark | first2 = GJ. | last3 = Kanarek | first3 = D. | title = Multiple peripheral pulmonary carcinoids and tumorlets of carcinoid type, with restrictive and obstructive lung disease. | journal = Am J Med | volume = 65 | issue = 2 | pages = 373-8 | month = Aug | year = 1978 | doi = | PMID = 356600 }}</ref> | |||
**Can mimicking metastatic disease.<ref name=pmid17400673>{{Cite journal | last1 = Aubry | first1 = MC. | last2 = Thomas | first2 = CF. | last3 = Jett | first3 = JR. | last4 = Swensen | first4 = SJ. | last5 = Myers | first5 = JL. | title = Significance of multiple carcinoid tumors and tumorlets in surgical lung specimens: analysis of 28 patients. | journal = Chest | volume = 131 | issue = 6 | pages = 1635-43 | month = Jun | year = 2007 | doi = 10.1378/chest.06-2788 | PMID = 17400673 }}</ref> | |||
**Often re-occur - but long term survival good. | |||
Presentation:<ref name=pmid16810137>{{Cite journal | last1 = Gungor | first1 = S. | last2 = Damadoglu | first2 = E. | last3 = Aybatli | first3 = A. | last4 = Yilmaz | first4 = A. | last5 = Kir | first5 = A. | last6 = Akkaya | first6 = E. | title = Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases. | journal = Med Sci Monit | volume = 12 | issue = 7 | pages = CR315-8 | month = Jul | year = 2006 | doi = | PMID = 16810137 }}</ref> | Presentation:<ref name=pmid16810137>{{Cite journal | last1 = Gungor | first1 = S. | last2 = Damadoglu | first2 = E. | last3 = Aybatli | first3 = A. | last4 = Yilmaz | first4 = A. | last5 = Kir | first5 = A. | last6 = Akkaya | first6 = E. | title = Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases. | journal = Med Sci Monit | volume = 12 | issue = 7 | pages = CR315-8 | month = Jul | year = 2006 | doi = | PMID = 16810137 }}</ref> | ||
Revision as of 02:05, 22 September 2015
| Typical carcinoid lung tumour | |
|---|---|
| Diagnosis in short | |
 Lung carcinoid. H&E stain. | |
|
| |
| Synonyms | lung carcinoid |
|
| |
| LM | stippled chromatin, usually nested architecture, no necrosis, low mitotic rate (see below) |
| LM DDx | atypical carcinoid lung tumour, pulmonary carcinoid tumourlet, lung adenocarcinoma |
| IHC | Ki-67 ~2% (0-7%) |
| Gross | well-circumscribed, solid, >=5 mm (definition) |
| Site | lung - see lung tumours |
|
| |
| Symptoms | +/-cough, +/-hemoptysis |
| Prevalence | not common |
| Radiology | usually central (85% of cases), well-circumscribed, solid |
| Prognosis | benign |
| Clin. DDx | other lung tumours |
| Treatment | excision to exclude other types of lung tumours & treat symptoms |
Typical carcinoid lung tumour, also lung carcinoid and carcinoid tumour of the lung, is a benign lung tumour, that is excised to exclude malignancy.
General
- Approximately 80% of lung carcinoids.[1]
- May be multiple.[2]
- Can mimicking metastatic disease.[3]
- Often re-occur - but long term survival good.
Presentation:[4]
- Cough.
- Hemoptysis.
Treatment:
- Surgical resection.[5]
Gross
- Well-circumscribed, solid.
- Location - central airways (85%), remainder peripheral.[6]
Microscopic
Features:
- Nests of cells.
- Stippled chromatin.
- Moderate cytoplasm.
- No necrosis.
- Low mitotic rate.
- Size criterion: >= 5 mm.[7][8]
DDx:
Images
Lung carcinoid - low mag. (WC)
Lung carcinoid - high mag. (WC)
Lung carcinoid - very high mag. (WC)
IHC
- Ki-67 ~2% (range 0-7%).[10]
Note:
- Atypical carcinoid is on average 17% (range 10-26%).[10]
Sign out
A. Lymph Node, Station 2L, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. B. Lymph Node, Station 4L, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. C. Lymph Node, Station 11L, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. D. Lung, Left Upper Lobe, Lobectomy: - Typical carcinoid tumour (12 mm maximal dimension). - Carcinoid tumourlet (2 mm maximal dimension). - Margins clear of tumour. - Please see tumour summary.
See also
References
- ↑ Naalsund, A.; Rostad, H.; Strøm, EH.; Lund, MB.; Strand, TE. (Apr 2011). "Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study.". Eur J Cardiothorac Surg 39 (4): 565-9. doi:10.1016/j.ejcts.2010.08.036. PMID 20888248.
- ↑ Miller, MA.; Mark, GJ.; Kanarek, D. (Aug 1978). "Multiple peripheral pulmonary carcinoids and tumorlets of carcinoid type, with restrictive and obstructive lung disease.". Am J Med 65 (2): 373-8. PMID 356600.
- ↑ Aubry, MC.; Thomas, CF.; Jett, JR.; Swensen, SJ.; Myers, JL. (Jun 2007). "Significance of multiple carcinoid tumors and tumorlets in surgical lung specimens: analysis of 28 patients.". Chest 131 (6): 1635-43. doi:10.1378/chest.06-2788. PMID 17400673.
- ↑ Gungor, S.; Damadoglu, E.; Aybatli, A.; Yilmaz, A.; Kir, A.; Akkaya, E. (Jul 2006). "Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases.". Med Sci Monit 12 (7): CR315-8. PMID 16810137.
- ↑ Caplin, ME.; Baudin, E.; Ferolla, P.; Filosso, P.; Garcia-Yuste, M.; Lim, E.; Oberg, K.; Pelosi, G. et al. (Aug 2015). "Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.". Ann Oncol 26 (8): 1604-20. doi:10.1093/annonc/mdv041. PMID 25646366.
- ↑ Meisinger, QC.; Klein, JS.; Butnor, KJ.; Gentchos, G.; Leavitt, BJ. (Nov 2011). "CT features of peripheral pulmonary carcinoid tumors.". AJR Am J Roentgenol 197 (5): 1073-80. doi:10.2214/AJR.10.5954. PMID 22021498.
- ↑ URL: http://pathhsw5m54.ucsf.edu/case7/image75.html. Accessed on: 23 January 2012.
- ↑ He, P.; Gu, X.; Wu, Q.; Lin, Y.; Gu, Y.; He, J. (Dec 2012). "Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis.". J Thorac Dis 4 (6): 655-8. doi:10.3978/j.issn.2072-1439.2012.06.11. PMID 23205296.
- ↑ Demirci, I.; Herold, S.; Kopp, A.; Flaßhove, M.; Klosterhalfen, B.; Janßen, H. (2012). "Overdiagnosis of a typical carcinoid tumor as an adenocarcinoma of the lung: a case report and review of the literature.". World J Surg Oncol 10: 19. doi:10.1186/1477-7819-10-19. PMID 22269186.
- ↑ 10.0 10.1 Liu, SZ.; Staats, PN.; Goicochea, L.; Alexiev, BA.; Shah, N.; Dixon, R.; Burke, AP. (2014). "Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung.". Diagn Pathol 9: 174. doi:10.1186/s13000-014-0174-z. PMID 25318848.