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Difference between revisions of "Case 67"
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→Chromosomal translocations: add clonality
(Created page with "===Provided clinical history=== XXX year old man/woman, YYY ===Site=== ZZZ ===Primary image=== 500px|link=|center| <center>Low magnificat...") |
(→Chromosomal translocations: add clonality) |
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===Provided clinical history=== | ===Provided clinical history=== | ||
73 year old man, colon cancer | |||
===Site=== | ===Site=== | ||
abdominal lymph node | |||
===Primary image=== | ===Primary image=== | ||
[[Image: | [[Image: Follicular lymphoma -- very low mag.jpg |500px|link=|center|]] | ||
<center> | <center>Very low magnification. [[H&E stain]].</center> | ||
{{hidden| | {{hidden|Low magnification|[[Image: Follicular lymphoma -- low mag.jpg |400px|link=|center|]] | ||
<center> | <center>Low magnification. [[H&E stain]].</center>}} | ||
{{hidden| | {{hidden|Very high magnification|[[Image: Follicular lymphoma -- very high mag.jpg |500px|link=|center|]] | ||
<center> | <center>Very high magnification. [[H&E stain]].</center>}} | ||
===Differential diagnosis=== | ===Differential diagnosis=== | ||
{{hidden|Differential diagnosis|<center> | {{hidden|Differential diagnosis|<center>[[Small cell lymphomas]]</center>}} | ||
===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>Biopsy proven sigmoid carcinoma. Mildly obese. Hemoglobin 103 g/L, WBC 23,000 lymphocytes/mm<sup>3</sup>.</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center> | {{hidden|Ask a colleague|<center>Have you done some stains? BCL2 should be informative.</center>}} | ||
====Stains==== | ====Stains==== | ||
| Line 82: | Line 82: | ||
| b72_3= | | b72_3= | ||
| bcatenin= | | bcatenin= | ||
| bcl2= | | bcl2= [[Image:Follicluar lymphoma - bcl2 -- low mag.jpg |400px|link=|center|]]<center>Patient's tissue - low magnification.</center> [[Image:Follicular lymphoma - control bcl2 -- low mag.jpg |200px|link=|center|]]<center>Control tissue - low magnification.</center> | ||
| bcl6= | | bcl6= '''POSITIVE''' | ||
| bclxl= | | bclxl= | ||
| c3= | | c3= | ||
| Line 90: | Line 90: | ||
| calretinin= | | calretinin= | ||
| cam5p2= | | cam5p2= | ||
| cd10= | | cd10= '''POSITIVE''' | ||
| cd117= | | cd117= | ||
| cd138= | | cd138= | ||
| cd15= | | cd15= | ||
| cd1a= | | cd1a= | ||
| cd20= | | cd20= '''POSITIVE''' | ||
| cd21= | | cd21= | ||
| cd23= | | cd23= '''NEGATIVE''' | ||
| cd3= | | cd3= '''NEGATIVE''' | ||
| cd30= | | cd30= | ||
| cd31= | | cd31= | ||
| Line 104: | Line 104: | ||
| cd35= | | cd35= | ||
| cd4= | | cd4= | ||
| cd43= | | cd43= '''NEGATIVE''' | ||
| cd45= | | cd45= '''POSITIVE''' | ||
| cd5= '''NEGATIVE''' | |||
| cd5= | |||
| cd56= | | cd56= | ||
| cd57= | | cd57= | ||
| Line 127: | Line 126: | ||
| cmv= | | cmv= | ||
| cmyc= | | cmyc= | ||
| cyclin_d1= | | cyclin_d1= '''NEGATIVE''' | ||
| d2_40= | | d2_40= | ||
| desmin= | | desmin= | ||
| Line 216: | Line 215: | ||
| wt1= | | wt1= | ||
}} | }} | ||
====Chromosomal translocations==== | ====Molecular testing==== | ||
=====Chromosomal translocations===== | |||
{{Case Translocations | {{Case Translocations | ||
| blank=Dr Torres would ask why! | | blank=Dr Torres would ask why! | ||
| Line 231: | Line 231: | ||
| t12_16liposar= | | t12_16liposar= | ||
| t12_22= | | t12_22= | ||
| t14_18= | | t14_18= '''PRESENT''' | ||
| t15_17= | | t15_17= | ||
| t16_21= | | t16_21= | ||
| Line 239: | Line 239: | ||
| tx_17= | | tx_17= | ||
| tx_18= | | tx_18= | ||
}} | |||
=====Other molecular tests===== | |||
{{Case Molecular | |||
| blank=Dr Torres would ask why! | |||
| alk = | |||
| b_cell_clone = Clonality '''PRESENT''' | |||
| bcl2 = | |||
| braf = | |||
| EBV_pcr = | |||
| egrf = | |||
| h3f3a = | |||
| hhv8_pcr = | |||
| identity_test = | |||
| idh1_2 = | |||
| jak2_v617f = | |||
| kit = | |||
| loh_1p19q = | |||
| t_cell_clone = Clonality '''ABSENT''' | |||
}} | }} | ||
===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center> | {{hidden|Diagnosis|<center>[[Follicular lymphoma]]</center>}} | ||
<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||
{{Cases navigation}} | {{Cases navigation}} | ||
| Line 251: | Line 270: | ||
[[Category:Cases]] | [[Category:Cases]] | ||
[[Category:Cases in lymph node pathology]] | |||
[[Category:Cases in | [[Category:Cases in lymph node pathology - junior]] | ||
- | [[Category:Cases in hematopathology]] | ||
[[Category:Cases in hematopathology - junior]] | |||
[[Category:Cases difficulty | [[Category:Cases difficulty 3]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | ||