Difference between revisions of "Typical carcinoid lung tumour"
Jump to navigation
Jump to search
| Line 38: | Line 38: | ||
*Cough. | *Cough. | ||
*Hemoptysis. | *Hemoptysis. | ||
Treatment: | |||
*Surgical resection.<ref name=pmid25646366>{{Cite journal | last1 = Caplin | first1 = ME. | last2 = Baudin | first2 = E. | last3 = Ferolla | first3 = P. | last4 = Filosso | first4 = P. | last5 = Garcia-Yuste | first5 = M. | last6 = Lim | first6 = E. | last7 = Oberg | first7 = K. | last8 = Pelosi | first8 = G. | last9 = Perren | first9 = A. | title = Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids. | journal = Ann Oncol | volume = 26 | issue = 8 | pages = 1604-20 | month = Aug | year = 2015 | doi = 10.1093/annonc/mdv041 | PMID = 25646366 }}</ref> | |||
==Gross== | ==Gross== | ||
Revision as of 20:28, 28 August 2015
| Typical carcinoid lung tumour | |
|---|---|
| Diagnosis in short | |
 Lung carcinoid. H&E stain. | |
|
| |
| Synonyms | lung carcinoid |
|
| |
| LM | stippled chromatin, usually nested architecture, no necrosis, low mitotic rate (see below) |
| LM DDx | atypical carcinoid lung tumour, pulmonary carcinoid tumourlet, lung adenocarcinoma |
| IHC | Ki-67 ~2% (0-7%) |
| Gross | well-circumscribed, solid, >=5 mm (definition) |
| Site | lung - see lung tumours |
|
| |
| Symptoms | +/-cough, +/-hemoptysis |
| Prevalence | not common |
| Radiology | usually central (85% of cases), well-circumscribed, solid |
| Prognosis | benign |
| Clin. DDx | other lung tumours |
| Treatment | excision to exclude other types of lung tumours & treat symptoms |
Typical carcinoid lung tumour, also lung carcinoid and carcinoid tumour of the lung, is a benign lung tumour, that is excised to exclude malignancy.
General
- Approximately 80% of lung carcinoids.[1]
Presentation:[2]
- Cough.
- Hemoptysis.
Treatment:
- Surgical resection.[3]
Gross
- Well-circumscribed, solid.
- Location - central airways (85%), remainder peripheral.[4]
Microscopic
Features:
- Nests of cells.
- Stippled chromatin.
- Moderate cytoplasm.
- No necrosis.
- Low mitotic rate.
- Size criterion: >= 5 mm.[5][6]
DDx:
Images
Lung carcinoid - low mag. (WC)
Lung carcinoid - high mag. (WC)
Lung carcinoid - very high mag. (WC)
IHC
- Ki-67 ~2% (range 0-7%).[8]
Note:
- Atypical carcinoid is on average 17% (range 10-26%).[8]
Sign out
A. Lymph Node, Station 2L, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. B. Lymph Node, Station 4L, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. C. Lymph Node, Station 11L, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. D. Lung, Left Upper Lobe, Lobectomy: - Typical carcinoid tumour (12 mm maximal dimension). - Carcinoid tumourlet (2 mm maximal dimension). - Margins clear of tumour. - Please see tumour summary.
See also
References
- ↑ Naalsund, A.; Rostad, H.; Strøm, EH.; Lund, MB.; Strand, TE. (Apr 2011). "Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study.". Eur J Cardiothorac Surg 39 (4): 565-9. doi:10.1016/j.ejcts.2010.08.036. PMID 20888248.
- ↑ Gungor, S.; Damadoglu, E.; Aybatli, A.; Yilmaz, A.; Kir, A.; Akkaya, E. (Jul 2006). "Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases.". Med Sci Monit 12 (7): CR315-8. PMID 16810137.
- ↑ Caplin, ME.; Baudin, E.; Ferolla, P.; Filosso, P.; Garcia-Yuste, M.; Lim, E.; Oberg, K.; Pelosi, G. et al. (Aug 2015). "Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.". Ann Oncol 26 (8): 1604-20. doi:10.1093/annonc/mdv041. PMID 25646366.
- ↑ Meisinger, QC.; Klein, JS.; Butnor, KJ.; Gentchos, G.; Leavitt, BJ. (Nov 2011). "CT features of peripheral pulmonary carcinoid tumors.". AJR Am J Roentgenol 197 (5): 1073-80. doi:10.2214/AJR.10.5954. PMID 22021498.
- ↑ URL: http://pathhsw5m54.ucsf.edu/case7/image75.html. Accessed on: 23 January 2012.
- ↑ He, P.; Gu, X.; Wu, Q.; Lin, Y.; Gu, Y.; He, J. (Dec 2012). "Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis.". J Thorac Dis 4 (6): 655-8. doi:10.3978/j.issn.2072-1439.2012.06.11. PMID 23205296.
- ↑ Demirci, I.; Herold, S.; Kopp, A.; Flaßhove, M.; Klosterhalfen, B.; Janßen, H. (2012). "Overdiagnosis of a typical carcinoid tumor as an adenocarcinoma of the lung: a case report and review of the literature.". World J Surg Oncol 10: 19. doi:10.1186/1477-7819-10-19. PMID 22269186.
- ↑ 8.0 8.1 Liu, SZ.; Staats, PN.; Goicochea, L.; Alexiev, BA.; Shah, N.; Dixon, R.; Burke, AP. (2014). "Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung.". Diagn Pathol 9: 174. doi:10.1186/s13000-014-0174-z. PMID 25318848.