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Difference between revisions of "Small vessel leukocytoclastic vasculitis"
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Small vessel leukocytoclastic vasculitis (view source)
Revision as of 03:59, 14 August 2015
, 03:59, 14 August 2015no edit summary
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| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = | | Tx = remove underlying cause; colchicine and/or dapsone; immunosuppression | ||
}} | }} | ||
'''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]]. | '''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]]. | ||
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==General== | ==General== | ||
*Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref> | *Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref> | ||
Has a very broad DDx:<ref name=pmid18948765/> | Has a very broad DDx:<ref name=pmid18948765/> | ||
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#*Paraneoplastic. | #*Paraneoplastic. | ||
#*Drugs. | #*Drugs. | ||
Clinical: | |||
*Palpable purpura, usu. lower extremity. | |||
Treatment - dependent on cause - may include:<ref name=pmid24756249>{{Cite journal | last1 = Goeser | first1 = MR. | last2 = Laniosz | first2 = V. | last3 = Wetter | first3 = DA. | title = A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis. | journal = Am J Clin Dermatol | volume = 15 | issue = 4 | pages = 299-306 | month = Aug | year = 2014 | doi = 10.1007/s40257-014-0076-6 | PMID = 24756249 }}</ref> | |||
*Remove underlying cause if it can be determined. | |||
*Colchicine and/or dapsone. | |||
*Immunosuppression. | |||
==Microscopic== | |||
Features:<ref name=pmid18948765/> | |||
*Small upper dermis vessels with: | |||
*#Neutrophils. | |||
*#*Fragmentation of [[neutrophil]]s (leukocytoclasia). | |||
*#Vessel damage: fibrin deposition (bright pink acellular stuff). | |||
DDx: | DDx: | ||