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Difference between revisions of "B cell small lymphocytic lymphoma/chronic lymphocytic leukemia"
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B cell small lymphocytic lymphoma/chronic lymphocytic leukemia (view source)
Revision as of 15:16, 13 August 2015
, 15:16, 13 August 2015→IHC
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[bone marrow]]/[[lymph nodes]] | | Site = blood + [[bone marrow]]/[[lymph nodes]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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| Symptoms = | | Symptoms = | ||
| Prevalence = common | | Prevalence = common | ||
| Bloodwork = | | Bloodwork = elevated WBC (≥5 × 10<sup>9</sup>/L) | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
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| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = | | Tx = often followup | ||
}} | }} | ||
'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. It typically afflicts older individuals. | '''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. It typically afflicts older individuals. | ||
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**May transform to an aggressive lymphoma - see below. | **May transform to an aggressive lymphoma - see below. | ||
*Older individuals. | *Older individuals. | ||
*Elevated WBC. | *Elevated WBC ≥5 × 10<sup>9</sup>/L - required for diagnosis (clinically).<ref>{{cite journal |author=Call TG, Norman AD, Hanson CA, ''et al.'' |title=Incidence of chronic lymphocytic leukemia and high-count monoclonal B-cell lymphocytosis using the 2008 guidelines |journal=Cancer |volume= |issue= |pages= |year=2014 |month=April |pmid=24711224 |doi=10.1002/cncr.28690 |url=}}</ref> | ||
===Richter's transformation=== | ===Richter's transformation=== | ||
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*CD38 -ve/+ve. | *CD38 -ve/+ve. | ||
**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal |author=Guarini A, Gaidano G, Mauro FR, ''et al.'' |title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features |journal=Blood |volume=102 |issue=3 |pages=1035–41 |year=2003 |month=August |pmid=12676780 |doi=10.1182/blood-2002-12-3639 |url=}}</ref> | **CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal |author=Guarini A, Gaidano G, Mauro FR, ''et al.'' |title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features |journal=Blood |volume=102 |issue=3 |pages=1035–41 |year=2003 |month=August |pmid=12676780 |doi=10.1182/blood-2002-12-3639 |url=}}</ref> | ||
===Panel=== | |||
A basic panel - based on ''Rizzo and Nassiri'':<ref name=lymphoma>{{Cite journal | last1 = Rizzo | first1 = K. | last2 = Nassiri| first2 = M. | title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. | journal = Lymphoma | volume = | issue = | pages = | month = | year = 2012 | doi =doi:10.1155/2012/346084| PMID = }}</ref> | |||
*CD5, CD10, BCL6, CD23, cyclin D1. | |||
Additional IHC: | |||
*CD20, CD3, CD43, BCL2. | |||
==Molecular== | ==Molecular== | ||