Thyroid gland nodular hyperplasia: Difference between revisions
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| Micro = typically follicles of variable size - may be microfollicular or solid; no nuclear changes of [[papillary thyroid carcinoma|PTC]]; no fibrous capsule | | Micro = typically follicles of variable size - may be microfollicular or solid; no nuclear changes of [[papillary thyroid carcinoma|PTC]]; no fibrous capsule | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[papillary thyroid carcinoma]], [[follicular thyroid adenoma]] | | LMDDx = [[papillary thyroid carcinoma]], [[follicular thyroid adenoma]], [[follicular thyroid carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Tx = surgical resection | | Tx = surgical resection | ||
}} | }} | ||
'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for | '''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for thyroidectomy. | ||
==General== | ==General== | ||
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**If you've seen a handful of thyroids you've seen this. | **If you've seen a handful of thyroids you've seen this. | ||
*Considered to be a combination of environmental factors (e.g. lack of iodine in the diet) and genetic factors (often with autosomal dominant inheritance).<ref name=pmid21487943>{{Cite journal | last1 = Paschke | first1 = R. | title = Molecular pathogenesis of nodular goiter. | journal = Langenbecks Arch Surg | volume = 396 | issue = 8 | pages = 1127-36 | month = Dec | year = 2011 | doi = 10.1007/s00423-011-0788-5 | PMID = 21487943 }}</ref> | *Considered to be a combination of environmental factors (e.g. lack of iodine in the diet) and genetic factors (often with autosomal dominant inheritance).<ref name=pmid21487943>{{Cite journal | last1 = Paschke | first1 = R. | title = Molecular pathogenesis of nodular goiter. | journal = Langenbecks Arch Surg | volume = 396 | issue = 8 | pages = 1127-36 | month = Dec | year = 2011 | doi = 10.1007/s00423-011-0788-5 | PMID = 21487943 }}</ref> | ||
==Gross== | ==Gross== | ||
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Image: Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg | FNA c/w AN. (WC/Euthman) | Image: Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg | FNA c/w AN. (WC/Euthman) | ||
</gallery> | </gallery> | ||
==Molecular== | |||
*Nodular hyperplasias may be clonal;<ref name=pmid1973172>{{Cite journal | last1 = Namba | first1 = H. | last2 = Matsuo | first2 = K. | last3 = Fagin | first3 = JA. | title = Clonal composition of benign and malignant human thyroid tumors. | journal = J Clin Invest | volume = 86 | issue = 1 | pages = 120-5 | month = Jul | year = 1990 | doi = 10.1172/JCI114673 | PMID = 1973172 }}</ref> however, this is not used for diagnosis and considered clinically irrelevant. | |||
==Sign out== | ==Sign out== | ||
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==See also== | ==See also== | ||
*[[Thyroid gland]]. | *[[Thyroid gland]]. | ||
*[[Thyroid cytopathology]]. | |||
==References== | ==References== | ||