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Difference between revisions of "Thyroid gland nodular hyperplasia"
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Thyroid gland nodular hyperplasia (view source)
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'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg | |||
| Width = | |||
| Caption = Thyroid FNA compatible with adenomatoid nodule. | |||
| Synonyms = nodular hyperplasia, adenomatoid nodule | |||
| Micro = typically follicles of variable size - may be microfollicular or solid; no nuclear changes of [[papillary thyroid carcinoma|PTC]]; no fibrous capsule | |||
| Subtypes = | |||
| LMDDx = [[papillary thyroid carcinoma]], [[follicular thyroid adenoma]], [[follicular thyroid carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = enlarged thyroid gland +/- distinct nodules | |||
| Grossing = | |||
| Site = [[thyroid gland]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = thyroid gland enlargement | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = malignancy of thyroid gland | |||
| Tx = surgical resection | |||
}} | |||
'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for thyroidectomy. | |||
==General== | ==General== | ||
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*Most common diagnosis in the thyroid. | *Most common diagnosis in the thyroid. | ||
**If you've seen a handful of thyroids you've seen this. | **If you've seen a handful of thyroids you've seen this. | ||
*Considered to be a combination of environmental factors (e.g. lack of iodine in the diet) and genetic factors (often with autosomal dominant inheritance).<ref name=pmid21487943>{{Cite journal | last1 = Paschke | first1 = R. | title = Molecular pathogenesis of nodular goiter. | journal = Langenbecks Arch Surg | volume = 396 | issue = 8 | pages = 1127-36 | month = Dec | year = 2011 | doi = 10.1007/s00423-011-0788-5 | PMID = 21487943 }}</ref> | |||
* | |||
==Gross== | ==Gross== | ||
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*[[Follicular thyroid adenoma]] - contained in a fibrous capsule. | *[[Follicular thyroid adenoma]] - contained in a fibrous capsule. | ||
*[[Follicular thyroid carcinoma]] - has fibrous capsule and invasion through it. | *[[Follicular thyroid carcinoma]] - has fibrous capsule and invasion through it. | ||
===Images=== | |||
<gallery> | |||
Image: Thyroid Benign Adenomatoid Nodule, FNA (5690954863).jpg | FNA c/w with AN. (WC/Euthman) | |||
Image: Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg | FNA c/w AN. (WC/Euthman) | |||
</gallery> | |||
==Molecular== | |||
*Nodular hyperplasias may be clonal;<ref name=pmid1973172>{{Cite journal | last1 = Namba | first1 = H. | last2 = Matsuo | first2 = K. | last3 = Fagin | first3 = JA. | title = Clonal composition of benign and malignant human thyroid tumors. | journal = J Clin Invest | volume = 86 | issue = 1 | pages = 120-5 | month = Jul | year = 1990 | doi = 10.1172/JCI114673 | PMID = 1973172 }}</ref> however, this is not used for diagnosis and considered clinically irrelevant. | |||
==Sign out== | ==Sign out== | ||
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==See also== | ==See also== | ||
*[[Thyroid gland]]. | *[[Thyroid gland]]. | ||
*[[Thyroid cytopathology]]. | |||
==References== | ==References== | ||