Difference between revisions of "Prostatic stromal tumour of uncertain malignant potential"

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Features:
Features:
*Overgrowth of spindle cells.
*Overgrowth of spindle cells.
*Plump nuclei.<ref name=pmid22388992/>
*+/-Multinucleation.


Note:
Note:
*Do not have [[necrosis]] and no or minimal mitotic activity - '''important'''.<ref name=pmid22388992/>
*May be seen with glandular abnormalities.<ref name=pmid21572264>{{Cite journal  | last1 = Nagar | first1 = M. | last2 = Epstein | first2 = JI. | title = Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP). | journal = Am J Surg Pathol | volume = 35 | issue = 6 | pages = 898-903 | month = Jun | year = 2011 | doi = 10.1097/PAS.0b013e318214f2f2 | PMID = 21572264 }}</ref>  
*May be seen with glandular abnormalities.<ref name=pmid21572264>{{Cite journal  | last1 = Nagar | first1 = M. | last2 = Epstein | first2 = JI. | title = Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP). | journal = Am J Surg Pathol | volume = 35 | issue = 6 | pages = 898-903 | month = Jun | year = 2011 | doi = 10.1097/PAS.0b013e318214f2f2 | PMID = 21572264 }}</ref>  



Revision as of 18:27, 5 August 2015

Prostatic stromal tumour of uncertain malignant potential, abbreviated PSTUMP, is a rare lesion of the prostatic stroma which cannot be definitively classified as benign or malignant.

It may be abbreviated as STUMP;[1] an abbreviation used for a uterine lesion of uncertain malignant potential.

It is also known as prostatic stromal proliferation of uncertain malignant potential (abbreviated PSPUMP).[2]

General

  • Rare.

Microscopic

Features:

  • Overgrowth of spindle cells.
  • Plump nuclei.[1]
  • +/-Multinucleation.

Note:

  • Do not have necrosis and no or minimal mitotic activity - important.[1]
  • May be seen with glandular abnormalities.[3]

DDx:

Images

IHC

Features:[1]

  • ER +ve.
  • PR +ve.
  • Desmin +ve/-ve.
  • CD34 +ve.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 De Berardinis, E.; Busetto, GM.; Antonini, G.; Giovannone, R.; Di Placido, M.; Magliocca, FM.; Di Silverio, A.; Gentile, V. (2012). "Incidental prostatic stromal tumor of uncertain malignant potential (STUMP): histopathological and immunohistochemical findings.". Urologia 79 (1): 65-8. doi:10.5301/RU.2012.9099. PMID 22388992.
  2. Gaudin, PB.; Rosai, J.; Epstein, JI. (Feb 1998). "Sarcomas and related proliferative lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases.". Am J Surg Pathol 22 (2): 148-62. PMID 9500215.
  3. Nagar, M.; Epstein, JI. (Jun 2011). "Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP).". Am J Surg Pathol 35 (6): 898-903. doi:10.1097/PAS.0b013e318214f2f2. PMID 21572264.
  4. Murer, LM.; Talmon, GA. (Nov 2014). "Stromal tumor of uncertain malignant potential of the prostate.". Arch Pathol Lab Med 138 (11): 1542-5. doi:10.5858/arpa.2013-0212-RS. PMID 25357117.