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Uterine cervix with atrophic changes (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Atrophic cervix -- very high mag.jpg | |||
| Width = | |||
| Caption = Atrophic cervix. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses | |||
| Subtypes = | |||
| LMDDx = [[HSIL]], immature [[squamous metaplasia of the uterine cervix|squamous metaplasia]] | |||
| Stains = | |||
| IHC = p16 -ve, Ki-67 rare basal cells | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[uterine cervix]] - exocervix | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = usually postmenopausal | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = normal - postmenopausal | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Uterine cervix with atrophic changes''' is relatively common and is important to recognize as it can mimic [[HSIL]]. | |||
It is also known as '''atrophy of the uterine cervix''', '''cervical atrophy''', '''atrophy of the cervix''' and '''cervix with atrophic changes'''. | |||
==General== | |||
*Common. | |||
*Post-menupausal. | |||
*Important to recognize and differentiate from [[HSIL]]. | |||
==Microscopic== | |||
Features - squamous cells: | |||
*Cells smaller. | |||
*Cytoplasm grey/blue. | |||
*No "dancing"/"sparkling" chromatin. | |||
*No mitoses. | |||
Notes: | |||
*Mitosis do not exclude the diagnosis.... but should make one think HSIL. | |||
DDx: | |||
*[[HSIL]]. | |||
*Immature [[squamous metaplasia of the uterine cervix|squamous metaplasia]].<ref name=pmid17824788/> | |||
===Images=== | |||
<gallery> | |||
Image: Atrophic cervix -- intermed mag.jpg | AC - intermed. mag. (WC) | |||
Image: Atrophic cervix - alt -- high mag.jpg | AC - high mag. (WC) | |||
Image: Atrophic cervix -- high mag.jpg | AC - high mag. (WC) | |||
Image: Atrophic cervix -- very high mag.jpg | AC - very high mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image: Atrophic cervix - 2 -- intermed mag.jpg | AC - intermed. mag. (WC) | |||
Image: Atrophic cervix - 2 -- high mag.jpg | AC - high mag. (WC) | |||
Image: Atrophic cervix - 2 -- very high mag.jpg | AC - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://nih.techriver.net/view.php?patientId=93 Atrophic cervix (nih.techriver.net)]. | |||
*[http://www.flickriver.com/photos/euthman/3884912676/ Atrophic cervix (flickriver.com/euthman)]. | |||
*[http://www.eurocytology.eu/static/eurocytology/image/mod1newa.jpg Atrophic changes in the vagina (eurocytology.eu)].<ref>URL: [http://www.eurocytology.eu/static/eurocytology/TUR/cervical/LP1ContentLcontC.html http://www.eurocytology.eu/static/eurocytology/TUR/cervical/LP1ContentLcontC.html]. Accessed on: 13 December 2013.</ref> | |||
==IHC== | |||
Features:<ref name=pmid17824788>{{Cite journal | last1 = Iaconis | first1 = L. | last2 = Hyjek | first2 = E. | last3 = Ellenson | first3 = LH. | last4 = Pirog | first4 = EC. | title = p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection. | journal = Arch Pathol Lab Med | volume = 131 | issue = 9 | pages = 1343-9 | month = Sep | year = 2007 | doi = 10.1043/1543-2165(2007)131[1343:PAKIIA]2.0.CO;2 | PMID = 17824788 }}</ref> | |||
*p16 -ve. | |||
*Ki-67 rare basal cells. | |||
==Sign out== | |||
<pre> | |||
UTERINE CERVIX, BIOPSY: | |||
- SQUAMOUS MUCOSA WITH ATROPHIC CHANGES. | |||
- BENIGN ENDOCERVICAL EPITHELIUM. | |||
- NEGATIVE FOR DYSPLASIA. | |||
COMMENT: | |||
A p16 immunostain is negative. A Ki-67 immunostain marks rare basal cells. | |||
</pre> | |||
==See also== | |||
*[[Uterine cervix]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Uterine cervix]] | |||
[[Category:Diagnosis]] | |||