Difference between revisions of "Nested urothelial carcinoma"

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'''Nested urothelial cell carcinoma''', also '''nested urothelial carcinoma''', is an aggressive subtype of [[urothelial carcinoma]] that has a bland morphology but an aggressive behaviour.
'''Nested urothelial carcinoma''' (abbreviated '''nested UC'''), also '''nested urothelial cell carcinoma''' (abbreviated '''nested UCC'''), is an aggressive subtype of [[urothelial carcinoma]] that has a bland morphology but an aggressive behaviour.


It is also known as '''nested variant urothelial cell carcinoma'''.
It is also known as '''nested variant of urothelial cell carcinoma'''.


==General==
==General==
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*[[von Brunn nests]].<ref name=pmid21836490>{{Cite journal  | last1 = Cox | first1 = R. | last2 = Epstein | first2 = JI. | title = Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. | journal = Am J Surg Pathol | volume = 35 | issue = 9 | pages = 1337-42 | month = Sep | year = 2011 | doi = 10.1097/PAS.0b013e318222a653 | PMID = 21836490 }}</ref>
*[[von Brunn nests]].<ref name=pmid21836490>{{Cite journal  | last1 = Cox | first1 = R. | last2 = Epstein | first2 = JI. | title = Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. | journal = Am J Surg Pathol | volume = 35 | issue = 9 | pages = 1337-42 | month = Sep | year = 2011 | doi = 10.1097/PAS.0b013e318222a653 | PMID = 21836490 }}</ref>
*[[Low grade papillary urothelial carcinoma]] with lamina propria invasion.
*[[Low grade papillary urothelial carcinoma]] with lamina propria invasion.
===Images===
<gallery>
Image:Nested_variant_of_urothelial_carcinoma_-_intermed_mag.jpg | Nested variant of urothelial carcinoma - intermed. mag. (WC/Nephron)
Image:Nested_variant_of_urothelial_carcinoma_-_high_mag.jpg | Nested variant of urothelial carcinoma - high mag. (WC/Nephron)
Image:Nested_variant_of_urothelial_carcinoma_-_very_high_mag.jpg | Nested variant of urothelial carcinoma - very high mag. (WC/Nephron)
</gallery>


==IHC==
==IHC==
*MIB-1 typically >15%.<ref name=pmid14681330/>
*MIB-1 typically >15%.<ref name=pmid14681330/>
==Sign out==
<pre>
URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION OF BLADDER TUMOUR (TURBT):
- INVASIVE LOW-GRADE UROTHELIAL CARCINOMA, NESTED VARIANT.
- TUMOUR PRESENT AT EDGE OF TISSUE.
- NO MUSCULARIS PROPRIA IDENTIFIED.
</pre>


==See also==
==See also==

Latest revision as of 06:00, 19 June 2015

Nested urothelial carcinoma (abbreviated nested UC), also nested urothelial cell carcinoma (abbreviated nested UCC), is an aggressive subtype of urothelial carcinoma that has a bland morphology but an aggressive behaviour.

It is also known as nested variant of urothelial cell carcinoma.

General

  • Aggressive behaviour despite bland histomorphology.[1]

Microscopic

Features:[2]

  • High density of well-circumscribed nests.
  • Mild-to-moderate nuclear atypia.
  • +/-Foci of unequivocal conventional urothelial carcinoma.
    • Focally solid or gland fusion.
    • Moderate-to-severe nuclear atypia +/- abundant mitoses.
  • +/-Extension into the muscularis propria.

DDx:

Images

IHC

  • MIB-1 typically >15%.[1]

Sign out

 URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION OF BLADDER TUMOUR (TURBT):
- INVASIVE LOW-GRADE UROTHELIAL CARCINOMA, NESTED VARIANT.
- TUMOUR PRESENT AT EDGE OF TISSUE.
- NO MUSCULARIS PROPRIA IDENTIFIED.

See also

References

  1. 1.0 1.1 Lin, O.; Cardillo, M.; Dalbagni, G.; Linkov, I.; Hutchinson, B.; Reuter, VE. (Dec 2003). "Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases.". Mod Pathol 16 (12): 1289-98. doi:10.1097/01.MP.0000094091.04541.FC. PMID 14681330.
  2. Talbert, ML.; Young, RH. (May 1989). "Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases.". Am J Surg Pathol 13 (5): 374-81. PMID 2712189.
  3. Cox, R.; Epstein, JI. (Sep 2011). "Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma.". Am J Surg Pathol 35 (9): 1337-42. doi:10.1097/PAS.0b013e318222a653. PMID 21836490.