Difference between revisions of "ELOC-mutated renal cell carcinoma"

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(+IHC)
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'''TCEB1-mutated renal cell carcinoma''', also '''renal cell carcinoma with TCEB1 mutation''', is an evolving entity that is similar to [[clear cell renal cell carcinoma]] and [[clear cell tubulopapillary renal cell carcinoma]].<ref>{{Cite journal  | last1 = Hakimi | first1 = AA. | last2 = Tickoo | first2 = SK. | last3 = Jacobsen | first3 = A. | last4 = Sarungbam | first4 = J. | last5 = Sfakianos | first5 = JP. | last6 = Sato | first6 = Y. | last7 = Morikawa | first7 = T. | last8 = Kume | first8 = H. | last9 = Fukayama | first9 = M. | title = TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype. | journal = Mod Pathol | volume = 28 | issue = 6 | pages = 845-53 | month = Jun | year = 2015 | doi = 10.1038/modpathol.2015.6 | PMID = 25676555 }}</ref>
'''TCEB1-mutated renal cell carcinoma''', also '''renal cell carcinoma with TCEB1 mutation''', is an evolving entity that is similar to [[clear cell renal cell carcinoma]] and [[clear cell tubulopapillary renal cell carcinoma]].<ref name=pmid25676555>{{Cite journal  | last1 = Hakimi | first1 = AA. | last2 = Tickoo | first2 = SK. | last3 = Jacobsen | first3 = A. | last4 = Sarungbam | first4 = J. | last5 = Sfakianos | first5 = JP. | last6 = Sato | first6 = Y. | last7 = Morikawa | first7 = T. | last8 = Kume | first8 = H. | last9 = Fukayama | first9 = M. | title = TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype. | journal = Mod Pathol | volume = 28 | issue = 6 | pages = 845-53 | month = Jun | year = 2015 | doi = 10.1038/modpathol.2015.6 | PMID = 25676555 }}</ref>


It should '''not''' be confused with [[TFEB renal cell carcinoma]], also known as ''renal tumour with t(6;11) translocation''.
It should '''not''' be confused with [[TFEB renal cell carcinoma]], also known as ''renal tumour with t(6;11) translocation''.
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==Microscopic==
==Microscopic==
Features:
Features:
*Clear cells with abundant cytoplasm.
*Clear cells with abundant cytoplasm and basal nuclei.  
*Usually [[ISUP nucleolar grade]] 2.
*Usually [[ISUP nucleolar grade]] 2.
*Fibromuscular bands - '''key feature'''.
*Fibromuscular bands - '''key feature'''.
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DDx:
DDx:
*[[Clear cell renal cell carcinoma]].
*[[Clear cell renal cell carcinoma]].
*[[Clear cell tubulopapillary renal cell carcinoma]].
*[[Clear cell tubulopapillary renal cell carcinoma]] - have luminal nuclei.
*[[Tuberous sclerosis-associated renal cell carcinoma]].
*[[Tuberous sclerosis-associated renal cell carcinoma]].
==IHC==
Features:<ref name=pmid25676555/>
*CK7 +ve.
*CD10 +ve.
*CK34betaE12 -ve.
**Usually positive in [[clear cell tubulopapillary renal cell carcinoma]].


==See also==
==See also==

Revision as of 18:54, 12 June 2015

TCEB1-mutated renal cell carcinoma, also renal cell carcinoma with TCEB1 mutation, is an evolving entity that is similar to clear cell renal cell carcinoma and clear cell tubulopapillary renal cell carcinoma.[1]

It should not be confused with TFEB renal cell carcinoma, also known as renal tumour with t(6;11) translocation.

General

  • Evolving entity.
  • TCEB1 (transcription elongation factor B, polypeptide 1) is part of a complex that binds with the product of the VHL gene;[2] thus, it acts as a tumour suppressor.

Gross

  • Cystic changes.

Microscopic

Features:

  • Clear cells with abundant cytoplasm and basal nuclei.
  • Usually ISUP nucleolar grade 2.
  • Fibromuscular bands - key feature.

DDx:

IHC

Features:[1]

See also

References

  1. ↑ 1.0 1.1 Hakimi, AA.; Tickoo, SK.; Jacobsen, A.; Sarungbam, J.; Sfakianos, JP.; Sato, Y.; Morikawa, T.; Kume, H. et al. (Jun 2015). "TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype.". Mod Pathol 28 (6): 845-53. doi:10.1038/modpathol.2015.6. PMID 25676555.
  2. ↑ URL: http://www.omim.org/entry/600788. Accessed on: 12 June 2015.
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