Account-creators
99
edits
Difference between revisions of "Traditional serrated adenoma"
Jump to navigation
Jump to search
no edit summary
| Line 4: | Line 4: | ||
| Width = Traditional serrated adenoma. [[H&E stain]]. | | Width = Traditional serrated adenoma. [[H&E stain]]. | ||
| Caption = | | Caption = | ||
| Micro = serrated, eosinophilic cytoplasm, villous-like architecture | | Micro = ectopic crypt foci (ECF), serrated, eosinophilic cytoplasm, villous-like architecture, "pine cone, fernlike, stellate pit pattern" | ||
| Subtypes = | | Subtypes = With and without high grade dysplasia, mixed with other types of polyps | ||
| LMDDx = [[villous adenoma]] | | LMDDx = [[villous adenoma]], [[hyperplasic polyp]], [[sessiles serrated adenoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = CK20 in the eosinophilic cells, absent in ECF; Ki67 (MIB1) stains ECF and absent in eosinophilic cells, MUC2+, MUC5CA+, MUC6-; In areas of dysplasia TP53+, nuclear B-catenin+; p16+ in late dysplasia | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = [[BRAF]] & [[KRAS]] | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Line 23: | Line 23: | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = q3year surveillance colonoscopy | ||
| Prognosis = benign (pre-malignant) | | Prognosis = benign (pre-malignant) | ||
| Other = | | Other = | ||