Difference between revisions of "Endolymphatic sac tumour"

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| Micro      = Papillary epithelial structures.
| Micro      = Papillary epithelial structures.
| Subtypes  =
| Subtypes  =
| LMDDx      = [[Plexus papilloma]]  
| LMDDx      = [[choroid plexus papilloma]], metastatic [[adenocarcinoma]]  
| Stains    =  
| Stains    =  
| IHC        = CK7 +ve
| IHC        = CK7 +ve
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| Clinicalhx =
| Clinicalhx =
| Signs      =  
| Signs      =  
| Symptoms  = Tinnitus, dizziness
| Symptoms  = tinnitus, dizziness
| Prevalence = very rare
| Prevalence = very rare
| Bloodwork  =
| Bloodwork  =
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| Tx        =
| Tx        =
}}
}}
'''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]].
'''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]].


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DDx:
DDx:
*Choroid plexus papilloma - when infiltrating cerebellopontine angle via petrous bone
*[[Choroid plexus papilloma]] - when infiltrating cerebellopontine angle via petrous bone.
*Metastatic [[adenocarcinoma]]
*[[Metastatic]] [[adenocarcinoma]].


===Images===
===Images===
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==IHC==
==IHC==
*CK7 +ve
*CK7 +ve.
*S-100 +ve (focally)
*S-100 +ve (focally).
*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>
*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>
*Kir 7.1-ve - discriminates tumor from plexus papilloma.<ref>{{Cite journal  | last1 = Schittenhelm | first1 = J. | last2 = Roser | first2 = F. | last3 = Tatagiba | first3 = M. | last4 = Beschorner | first4 = R. | title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. | journal = Am J Clin Pathol | volume = 138 | issue = 1 | pages = 85-9 | month = Jul | year = 2012 | doi = 10.1309/AJCPPRKNNL09JTLP | PMID = 22706862 }}</ref>
*Kir 7.1 -ve - discriminates tumour from plexus papilloma.<ref name=pmid22706862>{{Cite journal  | last1 = Schittenhelm | first1 = J. | last2 = Roser | first2 = F. | last3 = Tatagiba | first3 = M. | last4 = Beschorner | first4 = R. | title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. | journal = Am J Clin Pathol | volume = 138 | issue = 1 | pages = 85-9 | month = Jul | year = 2012 | doi = 10.1309/AJCPPRKNNL09JTLP | PMID = 22706862 }}</ref>


==See also==
==See also==
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[[Category:Head and neck pathology]]
[[Category:Head and neck pathology]]
[[Category:Neuropathology]]
[[Category:Neuropathology]]
[[Category:Papillary tumour]]
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