Difference between revisions of "Adenocarcinoma of the urinary bladder"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Adenocarcinoma of the urinary bladder -- intermed mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Adenocarcinoma of the urinary bladder. [[H&E stain]].
| Synonyms  = primary adenocarcinoma of the urinary bladder
| Synonyms  = primary adenocarcinoma of the urinary bladder
| Micro      = nuclear pleomorphism (may be mild), usually glandular differentiation (most common), no urothelial differentiation - '''essential'''
| Micro      = nuclear pleomorphism (may be mild), usually glandular differentiation (most common), no urothelial differentiation - '''essential'''
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*[[Metastatic]] adenocarcinoma.
*[[Metastatic]] adenocarcinoma.
**[[Colorectal adenocarcinoma]].
**[[Colorectal adenocarcinoma]].
===Images===
====Case 1====
<gallery>
Image: Adenocarcinoma of the urinary bladder -- low mag.jpg | AUB - low mag. (WC)
Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg | AUB - intermed. mag. (WC)
Image: Adenocarcinoma of the urinary bladder -- high mag.jpg | AUB - high mag. (WC)
</gallery>


==IHC==
==IHC==
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**[[Colorectal adenocarcinoma]] -ve.
**[[Colorectal adenocarcinoma]] -ve.
**[[Urothelial carcinoma]] +ve (~90% of cases).
**[[Urothelial carcinoma]] +ve (~90% of cases).
===Images===
====Case 1====
<gallery>
Image: Adenocarcinoma of the urinary bladder - beta-catenin -- low mag.jpg | AUB - beta-catenin - low mag. (WC)
Image: Adenocarcinoma of the urinary bladder - beta-catenin -- intermed mag.jpg | AUB - beta-catenin - intermed. mag. (WC)
Image: Adenocarcinoma of the urinary bladder - beta-catenin -- high mag.jpg | AUB - beta-catenin - high mag. (WC)
Image: Adenocarcinoma of the urinary bladder - beta-catenin -- very high mag.jpg | AUB - beta-catenin - very high mag. (WC)
</gallery>


==See also==
==See also==

Revision as of 16:35, 11 April 2015

Adenocarcinoma of the urinary bladder
Diagnosis in short

Adenocarcinoma of the urinary bladder. H&E stain.
Synonyms primary adenocarcinoma of the urinary bladder
LM nuclear pleomorphism (may be mild), usually glandular differentiation (most common), no urothelial differentiation - essential
LM DDx urachal carcinoma, invasive urothelial carcinoma with glandular differentiation, metastatic adenocarcinoma (esp. colorectal adenocarcinoma)
IHC CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin +ve (membranous, not nuclear)
Grossing notes radical cystectomy grossing, cystoprostatectomy grossing
Site urinary bladder
Prevalence rare
Treatment cystectomy

Adenocarcinoma of the urinary bladder, also primary adenocarcinoma of the urinary bladder and bladder adenocarcinoma, is a very uncommon malignant urinary bladder tumour.

General

Clinical:

Microscopic

Features:

  • Nuclear pleomorphism - may be mild.
  • Usually glandular differentiation (most common).
  • Without urothelial differentiation - essential.[3]

Subtypes:[2]

  • Glandular.
  • Papillary.
  • Colloidal (mucinous).
  • Signet ring cell carcinoma.
  • Clear cell carcinoma (also mesonephroid carcinoma).

DDx:

Images

Case 1

  • AUB - low mag. (WC)

  • AUB - intermed. mag. (WC)

  • AUB - high mag. (WC)

IHC

Features - variable:[4]

Images

Case 1

  • AUB - beta-catenin - low mag. (WC)

  • AUB - beta-catenin - intermed. mag. (WC)

  • AUB - beta-catenin - high mag. (WC)

  • AUB - beta-catenin - very high mag. (WC)

See also

References

  1. ↑ 1.0 1.1 Ranadive, NU.; Trivedi, VD.; Gadgil, NM. (Oct 1999). "Primary adenocarcinoma of the urinary bladder: a study of 6 cases from the pathologist's point of view.". Arch Esp Urol 52 (8): 906-11. PMID 11762445.
  2. ↑ 2.0 2.1 Abbas, M.; Kramer, MW.; Wolters, M.; Herrman, TR.; Becker, JU.; Kreipe, HH. (Feb 2013). "Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case.". Rare Tumors 5 (1): e3. doi:10.4081/rt.2013.e3. PMID 23772302.
  3. ↑ Zhong, M.; Gersbach, E.; Rohan, SM.; Yang, XJ. (Mar 2013). "Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.". Arch Pathol Lab Med 137 (3): 371-81. doi:10.5858/arpa.2012-0076-RA. PMID 23451748.
  4. ↑ Roy, S.; Parwani, AV. (Dec 2011). "Adenocarcinoma of the urinary bladder.". Arch Pathol Lab Med 135 (12): 1601-5. doi:10.5858/arpa.2009-0713-RS. PMID 22129192.
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