653
edits
Difference between revisions of "Sertoli-Leydig cell tumour"
Jump to navigation
Jump to search
→Microscopic
| Line 21: | Line 21: | ||
# +/- Sarcomatous features (mucinous glands, bone, cartilage). | # +/- Sarcomatous features (mucinous glands, bone, cartilage). | ||
*Well differentiated | Growth Patterns: | ||
** | **Well-differentiated | ||
** | ***Hollow or solid tubules of mature Sertoli cells with Leydig cells in the intervening stroma | ||
* | **Intermediate (most common) | ||
** | ***Jumbled admixture of dark blue Sertoli cells and Leydig cells | ||
** | ***Lobules comprising sheets of Sertoli cells | ||
** | ***Some areas of tubules. | ||
**Poorly differentiated | |||
***Masses of malignant spindle cells – sheets of cells can be reminiscent of fibrosarcoma or granulosa cell tumour | |||
***Tubules may be a very minor element | |||
**With heterologous element | |||
***Mucinous intestinal-type epithelium, cartilage, skeletal muscle | |||
***Heterologous elements can also occur with retiform or poorly differentiated tumours | |||
**Retiform | |||
***Tumour resembles rete testis/ovary with blunt papillae and irregular cleft-like spaces | |||
DDx: | DDx: | ||
*[[Endometrioid carcinoma of the ovary]] (sertoliform variant) - should be positive for EMA, negative for inhibin and calretinin. | *[[Endometrioid carcinoma of the ovary]] (sertoliform variant) - should be positive for EMA, negative for inhibin and calretinin. | ||
*Luteinized [[adult granulosa cell tumour]] - super rare, 50% of cell with eosinophilic cytoplasm, other findings of granulosa cell tumour, e.g. Call-Exner bodies. More likely to be keratin negative than a Sertoli-Leydig cell tumor. <ref name=pmid21804396>{{Cite journal | last1 = Ganesan | first1 = R. | last2 = Hirschowitz | first2 = L. | last3 = Baltrušaitytė | first3 = I. | last4 = McCluggage | first4 = WG. | title = Luteinized adult granulosa cell tumor--a series of 9 cases: revisiting a rare variant of adult granulosa cell tumor. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 452-9 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214b17f | PMID = 21804396 }}</ref> | *Luteinized [[adult granulosa cell tumour]] - super rare, 50% of cell with eosinophilic cytoplasm, other findings of granulosa cell tumour, e.g. Call-Exner bodies. More likely to be keratin negative than a Sertoli-Leydig cell tumor. <ref name=pmid21804396>{{Cite journal | last1 = Ganesan | first1 = R. | last2 = Hirschowitz | first2 = L. | last3 = Baltrušaitytė | first3 = I. | last4 = McCluggage | first4 = WG. | title = Luteinized adult granulosa cell tumor--a series of 9 cases: revisiting a rare variant of adult granulosa cell tumor. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 452-9 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214b17f | PMID = 21804396 }}</ref> | ||
*Ovarian carcinosarcoma - especially considering poorly differentiated versions with heterologous areas. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||