Difference between revisions of "Anal squamous cell carcinoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Anus SquamousCellCarcinoma SCC NonKeratinizing AIA SCCIS CTR.jpg
| Width      =
| Caption    = Anal squamous cell carcinoma. [[H&E stain]].
| Synonyms  =
| Micro      =
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[anus]]
| Assdx      =
| Syndromes  =
| Clinicalhx = +/-men who have sex with men, +/-immunodeficiency or immunosuppression
| Signs      =
| Symptoms  =
| Prevalence = most common anal cancer, overall uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        = surgical excision
}}
'''Anal squamous cell carcinoma''' is the most common type of [[anal cancer]].<ref name=pmid25741135>{{Cite journal  | last1 = Ghosn | first1 = M. | last2 = Kourie | first2 = HR. | last3 = Abdayem | first3 = P. | last4 = Antoun | first4 = J. | last5 = Nasr | first5 = D. | title = Anal cancer treatment: Current status and future perspectives. | journal = World J Gastroenterol | volume = 21 | issue = 8 | pages = 2294-2302 | month = Feb | year = 2015 | doi = 10.3748/wjg.v21.i8.2294 | PMID = 25741135 }}</ref>
'''Anal squamous cell carcinoma''' is the most common type of [[anal cancer]].<ref name=pmid25741135>{{Cite journal  | last1 = Ghosn | first1 = M. | last2 = Kourie | first2 = HR. | last3 = Abdayem | first3 = P. | last4 = Antoun | first4 = J. | last5 = Nasr | first5 = D. | title = Anal cancer treatment: Current status and future perspectives. | journal = World J Gastroenterol | volume = 21 | issue = 8 | pages = 2294-2302 | month = Feb | year = 2015 | doi = 10.3748/wjg.v21.i8.2294 | PMID = 25741135 }}</ref>


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==General==
==General==
*Most common form of anal cancer.<ref name=pmid25741135/>
*Most common form of anal cancer.<ref name=pmid25741135/>
*Overall anal cancer uncommon.<ref name=pmid25741135/>
*Strong association with [[HPV]].<ref name=pmid23616200>{{Cite journal  | last1 = Cornall | first1 = AM. | last2 = Roberts | first2 = JM. | last3 = Garland | first3 = SM. | last4 = Hillman | first4 = RJ. | last5 = Grulich | first5 = AE. | last6 = Tabrizi | first6 = SN. | title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. | journal = Int J Cancer | volume = 133 | issue = 9 | pages = 2253-8 | month = Nov | year = 2013 | doi = 10.1002/ijc.28228 | PMID = 23616200 }}</ref>
*Strong association with [[HPV]].<ref name=pmid23616200>{{Cite journal  | last1 = Cornall | first1 = AM. | last2 = Roberts | first2 = JM. | last3 = Garland | first3 = SM. | last4 = Hillman | first4 = RJ. | last5 = Grulich | first5 = AE. | last6 = Tabrizi | first6 = SN. | title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. | journal = Int J Cancer | volume = 133 | issue = 9 | pages = 2253-8 | month = Nov | year = 2013 | doi = 10.1002/ijc.28228 | PMID = 23616200 }}</ref>



Revision as of 18:07, 19 March 2015

Anal squamous cell carcinoma
Diagnosis in short

Anal squamous cell carcinoma. H&E stain.
Site anus

Clinical history +/-men who have sex with men, +/-immunodeficiency or immunosuppression
Prevalence most common anal cancer, overall uncommon
Treatment surgical excision

Anal squamous cell carcinoma is the most common type of anal cancer.[1]

It is also known as anal squamous carcinoma and squamous cell carcinoma of the anus.

General

  • Most common form of anal cancer.[1]
  • Overall anal cancer uncommon.[1]
  • Strong association with HPV.[2]

Risk factors:[3]

  • Men who have sex with men.
  • Immunosuppressed.
  • HIV infection.

Microscopic

Features:

DDx:

IHC

  • p16 +ve.[4]
  • CDX2 -ve/+ve.

Sign out

RECTUM, DISTAL, BIOPSY:
- INVASIVE SQUAMOUS CELL CARCINOMA.

See also

References

  1. 1.0 1.1 1.2 Ghosn, M.; Kourie, HR.; Abdayem, P.; Antoun, J.; Nasr, D. (Feb 2015). "Anal cancer treatment: Current status and future perspectives.". World J Gastroenterol 21 (8): 2294-2302. doi:10.3748/wjg.v21.i8.2294. PMID 25741135.
  2. Cornall, AM.; Roberts, JM.; Garland, SM.; Hillman, RJ.; Grulich, AE.; Tabrizi, SN. (Nov 2013). "Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11.". Int J Cancer 133 (9): 2253-8. doi:10.1002/ijc.28228. PMID 23616200.
  3. Kutlubay, Z.; Engin, B.; Zara, T.; Tüzün, Y.. "Anogenital malignancies and premalignancies: Facts and controversies.". Clin Dermatol 31 (4): 362-73. doi:10.1016/j.clindermatol.2013.01.003. PMID 23806153.
  4. 4.0 4.1 Gunia, S.; Koch, S.; May, M. (Feb 2013). "Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis?". J Clin Pathol 66 (2): 109-12. doi:10.1136/jclinpath-2012-201138. PMID 23105122.