Difference between revisions of "Spindle cell lesions"
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Revision as of 03:37, 22 May 2010
Spindle cell lesions are seen frequent enough that one ought to have a solid approach to 'em.
General DDx
Spindle cells should make think:
- Nerve.
- Muscle.
- Smooth.
- Skeletal.
- Other.
Malignant fibrous histiocytoma
Work-up (MSH):
- CD34 - GIST, angiosarcoma.
- S100 - neural.
- Desmin - smooth muscle.
- MIB-1 - proliferation.
- CD99 - small blue cell tumours.
- Bcl-2.
- PGP 9.5.
- SMMS - smooth muscle.
- Caldesmon - muscle.
- PDGFR - GIST.
- DOG-1 - associated with BRCA1.