Ménétrier's disease: Difference between revisions

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~~#redirect~~ [[~~Stomach#M~~.C3.~~A9n~~.C3.~~A9trier~~.~~27s_disease]~~]

{{ Infobox diagnosis

| Name = {{PAGENAME}}

| Image = Ménétrier's disease -- very low mag.jpg

| Width =

| Caption = Biopsy compatible with Ménétrier's disease. [[H&E stain]].

| Synonyms = diffuse foveolar cell hyperplasia, hypertrophic protein-losing gastropathy,

| Micro = marked foveolar cell hyperplasia, decreased parietal cells, +/-inflammation

| Subtypes =

| LMDDx = [[Cronkhite-Canada syndrome]], [[hyperplastic polyp of the stomach]]

| Stains =

| IHC =

| EM =

| Molecular =

| IF =

| Gross = "bag of worms" appearance - very thick gastric folds

| Grossing =

| Site = [[stomach]]

| Assdx = [[gastric adenocarcinoma]]

| Syndromes =

| Clinicalhx =

| Signs = emesis (intractible), peripheral edema

| Symptoms = abdominal pain

| Prevalence = extremely rare

| Bloodwork =

| Rads =

| Endoscopy = very thick gastric folds

| Prognosis =

| Other =

| ClinDDx = [[gastric cancer]]

}}

'''Ménétrier's disease''' is a very rare pathology of the [[stomach]]. It is also known as '''diffuse foveolar cell hyperplasia''',<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref> and '''hypertrophic protein-losing gastropathy'''.<ref name=pmid24092036>{{Cite journal | last1 = Hillman | first1 = MM. | last2 = Meinarde | first2 = LL. | last3 = Furnes | first3 = RA. | last4 = Daruich | first4 = ML. | last5 = Riva | first5 = V. | last6 = Cuestas | first6 = E. | title = [Protein losing gastroenteropathy and possible relationship to cytomegalovirus infection: Ménétrier disease in a child]. | journal = Arch Argent Pediatr | volume = 111 | issue = 5 | pages = 446-9 | month = Oct | year = 2013 | doi = 10.1590/S0325-00752013000500016 | PMID = 24092036 }}</ref><ref name=pmid1298040>{{Cite journal | last1 = Meuwissen | first1 = SG. | last2 = Ridwan | first2 = BU. | last3 = Hasper | first3 = HJ. | last4 = Innemee | first4 = G. | title = Hypertrophic protein-losing gastropathy. A retrospective analysis of 40 cases in The Netherlands. The Dutch Ménétrier Study Group. | journal = Scand J Gastroenterol Suppl | volume = 194 | issue = | pages = 1-7 | month = | year = 1992 | doi = | PMID = 1298040 }}</ref>

==General==

*Super rare.

*Increased risk of [[gastric adenocarcinoma]].<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref>

Clinical:<ref name=pmid20926644>{{Cite journal | last1 = Rich | first1 = A. | last2 = Toro | first2 = TZ. | last3 = Tanksley | first3 = J. | last4 = Fiske | first4 = WH. | last5 = Lind | first5 = CD. | last6 = Ayers | first6 = GD. | last7 = Piessevaux | first7 = H. | last8 = Washington | first8 = MK. | last9 = Coffey | first9 = RJ. | title = Distinguishing Ménétrier's disease from its mimics. | journal = Gut | volume = 59 | issue = 12 | pages = 1617-24 | month = Dec | year = 2010 | doi = 10.1136/gut.2010.220061 | PMID = 20926644 }}</ref>

*Classical: nausea, emesis, abdominal pain and peripheral edema.

**Emesis (intractable) - '''most important'''.

Other:

*Gastric mass (may mimic cancer).

*Hypochlorhydria.

*Protein loss (hypoalbuminemia) - leads to peripheral edema.

Epidemiology:

*Men > women.

*Adults usually 50s.‡

*Associated with [[ulcerative colitis]].

Treatment:

*EGFR inhibitors.<ref name=pmid18321437>{{Cite journal | last1 = Toubia | first1 = N. | last2 = Schubert | first2 = ML. | title = Menetrier's Disease. | journal = Curr Treat Options Gastroenterol | volume = 11 | issue = 2 | pages = 103-8 | month = Apr | year = 2008 | doi = | PMID = 18321437 }}</ref>

*Gastrectomy.

Note:

*‡ A similar constellation of symptoms can be seen in children and may be associated with [[CMV]] infection.<ref name=pmid1298040/><ref>{{Cite journal | last1 = Kindermann | first1 = A. | last2 = Koletzko | first2 = S. | title = [Protein-losing giant fold gastritis in childhood--a case report and differentiation from Ménétrier disease of adulthood]. | journal = Z Gastroenterol | volume = 36 | issue = 2 | pages = 165-71 | month = Feb | year = 1998 | doi = | PMID = 9544500 }}</ref>

==Gross==

*"Bag of worms" appearance - very thick gastric folds.

===Images===

Image:Menetrier.jpg | Ménétrier's disease. (WC/AFIP)

</gallery>

==Microscopic==

Features:<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref>

*Foveolar cell hyperplasia - '''key feature'''.

*Decreased parietal cells.

*+/-Inflammation.

DDx:

*[[Cronkhite-Canada syndrome]].<ref name="pmid11428328">{{cite journal |author=Junnarkar SP, Sloan JM, Johnston BT, Laird JD, Irwin ST |title=Cronkhite-Canada syndrome |journal=The Ulster medical journal |volume=70 |issue=1 |pages=56–8 |year=2001 |month=May |pmid=11428328 |pmc=2449205 |doi= |url=}}</ref>

*[[Hyperplastic polyp of the stomach]].

===Images===

Image: Ménétrier's disease -- very low mag.jpg | MD - very low mag. (WC)

Image: Ménétrier's disease -- low mag.jpg | MD - low mag. (WC)

Image: Ménétrier's disease - alt -- low mag.jpg | MD - low mag. (WC)

Image: Ménétrier's disease -- intermed mag.jpg | MD - intermed. mag. (WC)

Image: Ménétrier's disease -- high mag.jpg | MD - high mag. (WC)

</gallery>

www:

*[http://path.upmc.edu/cases/case36.html Ménétrier's disease - low quality images (upmc.edu)].

*[http://radiographics.rsna.org/content/29/1/297.full.pdf Ménétrier's disease - several images from the AFIP (rsna.org)].<ref name=pmid19168850>{{Cite journal | last1 = Friedman | first1 = J. | last2 = Platnick | first2 = J. | last3 = Farruggia | first3 = S. | last4 = Khilko | first4 = N. | last5 = Mody | first5 = K. | last6 = Tyshkov | first6 = M. | title = Ménétrier disease. | journal = Radiographics | volume = 29 | issue = 1 | pages = 297-301 | month = | year = | doi = 10.1148/rg.291075216 | PMID = 19168850 | URL = http://radiographics.rsnajnls.org/cgi/pmidlookup?view=long&pmid=19168850 }}</ref>

==See also==

*[[Stomach]].

==References==

[[Category:Stomach]]

[[Category:Diagnosis]]

@@ Line 1: / Line 1: @@
-#redirect [[Stomach#M.C3.A9n.C3.A9trier.27s_disease]]
+{{ Infobox diagnosis
+| Name       = {{PAGENAME}}
+| Image      = Ménétrier's disease -- very low mag.jpg
+| Width      =
+| Caption    = Biopsy compatible with Ménétrier's disease. [[H&E stain]].
+| Synonyms   = diffuse foveolar cell hyperplasia, hypertrophic protein-losing gastropathy,
+| Micro      = marked foveolar cell hyperplasia, decreased parietal cells, +/-inflammation
+| Subtypes   =
+| LMDDx      = [[Cronkhite-Canada syndrome]], [[hyperplastic polyp of the stomach]]
+| Stains     =
+| IHC        =
+| EM         =
+| Molecular  =
+| IF         =
+| Gross      = "bag of worms" appearance - very thick gastric folds
+| Grossing   =
+| Site       = [[stomach]]
+| Assdx      = [[gastric adenocarcinoma]]
+| Syndromes  =
+| Clinicalhx =
+| Signs      = emesis (intractible), peripheral edema
+| Symptoms   = abdominal pain
+| Prevalence = extremely rare
+| Bloodwork  =
+| Rads       =
+| Endoscopy  = very thick gastric folds
+| Prognosis  =
+| Other      =
+| ClinDDx    = [[gastric cancer]]
+}}
+'''Ménétrier's disease''' is a very rare pathology of the [[stomach]]. It is also known as '''diffuse foveolar cell hyperplasia''',<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref> and '''hypertrophic protein-losing gastropathy'''.<ref name=pmid24092036>{{Cite journal  | last1 = Hillman | first1 = MM. | last2 = Meinarde | first2 = LL. | last3 = Furnes | first3 = RA. | last4 = Daruich | first4 = ML. | last5 = Riva | first5 = V. | last6 = Cuestas | first6 = E. | title = [Protein losing gastroenteropathy and possible relationship to cytomegalovirus infection: Ménétrier disease in a child]. | journal = Arch Argent Pediatr | volume = 111 | issue = 5 | pages = 446-9 | month = Oct | year = 2013 | doi = 10.1590/S0325-00752013000500016 | PMID = 24092036 }}</ref><ref name=pmid1298040>{{Cite journal  | last1 = Meuwissen | first1 = SG. | last2 = Ridwan | first2 = BU. | last3 = Hasper | first3 = HJ. | last4 = Innemee | first4 = G. | title = Hypertrophic protein-losing gastropathy. A retrospective analysis of 40 cases in The Netherlands. The Dutch Ménétrier Study Group. | journal = Scand J Gastroenterol Suppl | volume = 194 | issue =  | pages = 1-7 | month =  | year = 1992 | doi =  | PMID = 1298040 }}</ref>
+==General==
+*Super rare.
+*Increased risk of [[gastric adenocarcinoma]].<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref>
+Clinical:<ref name=pmid20926644>{{Cite journal  | last1 = Rich | first1 = A. | last2 = Toro | first2 = TZ. | last3 = Tanksley | first3 = J. | last4 = Fiske | first4 = WH. | last5 = Lind | first5 = CD. | last6 = Ayers | first6 = GD. | last7 = Piessevaux | first7 = H. | last8 = Washington | first8 = MK. | last9 = Coffey | first9 = RJ. | title = Distinguishing Ménétrier's disease from its mimics. | journal = Gut | volume = 59 | issue = 12 | pages = 1617-24 | month = Dec | year = 2010 | doi = 10.1136/gut.2010.220061 | PMID = 20926644 }}</ref>
+*Classical: nausea, emesis, abdominal pain and peripheral edema.
+**Emesis (intractable) - '''most important'''.
+Other:
+*Gastric mass (may mimic cancer).
+*Hypochlorhydria.
+*Protein loss (hypoalbuminemia) - leads to peripheral edema.
+Epidemiology:
+*Men > women.
+*Adults usually 50s.‡
+*Associated with [[ulcerative colitis]].
+Treatment:
+*EGFR inhibitors.<ref name=pmid18321437>{{Cite journal  | last1 = Toubia | first1 = N. | last2 = Schubert | first2 = ML. | title = Menetrier's Disease. | journal = Curr Treat Options Gastroenterol | volume = 11 | issue = 2 | pages = 103-8 | month = Apr | year = 2008 | doi =  | PMID = 18321437 }}</ref>
+*Gastrectomy.
+Note:
+*‡ A similar constellation of symptoms can be seen in children and may be associated with [[CMV]] infection.<ref name=pmid1298040/><ref>{{Cite journal  | last1 = Kindermann | first1 = A. | last2 = Koletzko | first2 = S. | title = [Protein-losing giant fold gastritis in childhood--a case report and differentiation from Ménétrier disease of adulthood]. | journal = Z Gastroenterol | volume = 36 | issue = 2 | pages = 165-71 | month = Feb | year = 1998 | doi =  | PMID = 9544500 }}</ref>
+==Gross==
+*"Bag of worms" appearance - very thick gastric folds.
+===Images===
+<gallery>
+Image:Menetrier.jpg | Ménétrier's disease. (WC/AFIP)
+</gallery>
+==Microscopic==
+Features:<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref>
+*Foveolar cell hyperplasia - '''key feature'''.
+*Decreased parietal cells.
+*+/-Inflammation.
+DDx:
+*[[Cronkhite-Canada syndrome]].<ref name="pmid11428328">{{cite journal |author=Junnarkar SP, Sloan JM, Johnston BT, Laird JD, Irwin ST |title=Cronkhite-Canada syndrome |journal=The Ulster medical journal |volume=70 |issue=1 |pages=56–8 |year=2001 |month=May |pmid=11428328 |pmc=2449205 |doi= |url=}}</ref>
+*[[Hyperplastic polyp of the stomach]].
+===Images===
+<gallery>
+Image: Ménétrier's disease -- very low mag.jpg | MD - very low mag. (WC)
+Image: Ménétrier's disease -- low mag.jpg | MD - low mag. (WC)
+Image: Ménétrier's disease - alt -- low mag.jpg | MD - low mag. (WC)
+Image: Ménétrier's disease -- intermed mag.jpg | MD - intermed. mag. (WC)
+Image: Ménétrier's disease -- high mag.jpg | MD - high mag. (WC)
+</gallery>
+www:
+*[http://path.upmc.edu/cases/case36.html Ménétrier's disease - low quality images (upmc.edu)].
+*[http://radiographics.rsna.org/content/29/1/297.full.pdf Ménétrier's disease - several images from the AFIP (rsna.org)].<ref name=pmid19168850>{{Cite journal  | last1 = Friedman | first1 = J. | last2 = Platnick | first2 = J. | last3 = Farruggia | first3 = S. | last4 = Khilko | first4 = N. | last5 = Mody | first5 = K. | last6 = Tyshkov | first6 = M. | title = Ménétrier disease. | journal = Radiographics | volume = 29 | issue = 1 | pages = 297-301 | month =  | year =  | doi = 10.1148/rg.291075216 | PMID = 19168850 | URL = http://radiographics.rsnajnls.org/cgi/pmidlookup?view=long&pmid=19168850 }}</ref>
+==See also==
+*[[Stomach]].
+==References==
+{{Reflist|2}}
+[[Category:Stomach]]
 [[Category:Diagnosis]]

Ménétrier's disease: Difference between revisions

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