Difference between revisions of "Multilocular cystic renal neoplasm of low malignant potential"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
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| Synonyms = multilocular clear cell renal cell carcinoma, multilocular cystic renal cell neoplasms of low malignant potential (proposed name) | |||
| Micro = thin septa with (polygonal) cells with a clear cytoplasm, fibrous capsule (surrounds tumour), +/-calcification | |||
| Subtypes = | |||
| LMDDx = [[cystic renal disease]] with macrophages in the septa, cystic [[clear cell renal cell carcinoma]], [[tubulocystic carcinoma]] | |||
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| IF = | |||
| Gross = completely cystic - no solid components, well-circumscribed | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[kidney tumours]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare (case reports) | |||
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| Prognosis = very good | |||
| Other = | |||
| ClinDDx = other cystic renal tumours (e.g. cystic [[clear cell renal cell carcinoma]]), cystic renal disease | |||
| Tx = | |||
}} | |||
'''Multilocular cystic renal cell carcinoma''', abbreviated '''MCRCC''', is a rare [[kidney tumour]]. | '''Multilocular cystic renal cell carcinoma''', abbreviated '''MCRCC''', is a rare [[kidney tumour]]. | ||
Revision as of 05:47, 5 January 2015
Multilocular cystic renal neoplasm of low malignant potential | |
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Diagnosis in short | |
| |
Synonyms | multilocular clear cell renal cell carcinoma, multilocular cystic renal cell neoplasms of low malignant potential (proposed name) |
| |
LM | thin septa with (polygonal) cells with a clear cytoplasm, fibrous capsule (surrounds tumour), +/-calcification |
LM DDx | cystic renal disease with macrophages in the septa, cystic clear cell renal cell carcinoma, tubulocystic carcinoma |
Gross | completely cystic - no solid components, well-circumscribed |
Site | kidney - see kidney tumours |
| |
Prevalence | rare (case reports) |
Prognosis | very good |
Clin. DDx | other cystic renal tumours (e.g. cystic clear cell renal cell carcinoma), cystic renal disease |
Multilocular cystic renal cell carcinoma, abbreviated MCRCC, is a rare kidney tumour.
It is also known as multilocular clear cell renal cell carcinoma.[1]
As the behaviour of the tumour is very good, it has be proposed that this entity be renamed multilocular cystic renal cell neoplasms of low malignant potential.[2]
General
Gross
Features:[3]
- Completely cystic with thin septa.
- No solid nodules - required for diagnosis.[5]
- Well circumscribed.
Note:
- This tumour, radiologically, can often be separated from other cystic tumours.[6]
Microscopic
- Thin septa with (polygonal) cells with a clear cytoplasm - required.
- Fibrous capsule (surrounds tumour) - required.
- +/-Calcification (common).
DDx:
- Cystic renal disease with macrophages in the septa.
- Cystic clear cell renal cell carcinoma.
- Tubulocystic carcinoma.
IHC
- EMA +ve.
- Keratins +ve.
- CD68 -ve.
See also
References
- ↑ Chowdhury, AR.; Chakraborty, D.; Bhattacharya, P.; Dey, RK. (Apr 2013). "Multilocular cystic renal cell carcinoma a diagnostic dilemma: A case report in a 30-year-old woman.". Urol Ann 5 (2): 119-21. doi:10.4103/0974-7796.110012. PMID 23798872.
- ↑ Montironi, R.; Mazzucchelli, R.; Scarpelli, M.; Lopez-Beltran, A.; Cheng, L. (Dec 2013). "Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma.". Histol Histopathol 28 (12): 1555-66. PMID 23893851.
- ↑ 3.0 3.1 3.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 292. ISBN 978-0781765275.
- ↑ Agarwal, S.; Agrawal, U.; Mohanty, NK.; Saxena, S. (Mar 2011). "Multilocular cystic renal cell carcinoma: a case report of a rare entity.". Arch Pathol Lab Med 135 (3): 290-2. doi:10.1043/2010-0243-LE.1. PMID 21366448.
- ↑ 5.0 5.1 Eble, JN.; Bonsib, SM. (Feb 1998). "Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis.". Semin Diagn Pathol 15 (1): 2-20. PMID 9503503.
- ↑ You, D.; Shim, M.; Jeong, IG.; Song, C.; Kim, JK.; Ro, JY.; Hong, JH.; Ahn, H. et al. (Jul 2011). "Multilocular cystic renal cell carcinoma: clinicopathological features and preoperative prediction using multiphase computed tomography.". BJU Int. doi:10.1111/j.1464-410X.2011.10247.x. PMID 21722289.