Difference between revisions of "TFEB-rearranged renal cell carcinoma"

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'''Renal tumour with t(6;11) translocation''', also '''t(6;11) renal cell carcinoma''', is a rare [[kidney tumour]] seen primarily in children.
'''Renal tumour with t(6;11) translocation''', also '''t(6;11) renal cell carcinoma''', is a rare [[kidney tumour]] seen primarily in children.
It also known as '''TFEB RCC'''.<ref name=pmid24877033/>


==General==
==General==
*Not common.
*Very rare - approximately 2 dozen reported cases as of 2014.<ref name=pmid24877033/><ref name=pmid22892601>{{Cite journal  | last1 = Argani | first1 = P. | last2 = Yonescu | first2 = R. | last3 = Morsberger | first3 = L. | last4 = Morris | first4 = K. | last5 = Netto | first5 = GJ. | last6 = Smith | first6 = N. | last7 = Gonzalez | first7 = N. | last8 = Illei | first8 = PB. | last9 = Ladanyi | first9 = M. | title = Molecular confirmation of t(6;11)(p21;q12) renal cell carcinoma in archival paraffin-embedded material using a break-apart TFEB FISH assay expands its clinicopathologic spectrum. | journal = Am J Surg Pathol | volume = 36 | issue = 10 | pages = 1516-26 | month = Oct | year = 2012 | doi = 10.1097/PAS.0b013e3182613d8f | PMID = 22892601 }}</ref>
*[[Lymph node metastases]] are common.
*[[Lymph node metastases]] are common.
*Essentially a pediatric tumour - case report of an adult.<ref name=pmid21884304>{{Cite journal  | last1 = Ishihara | first1 = A. | last2 = Yamashita | first2 = Y. | last3 = Takamori | first3 = H. | last4 = Kuroda | first4 = N. | title = Renal carcinoma with (6;11)(p21;q12) translocation: Report of an adult case. | journal = Pathol Int | volume = 61 | issue = 9 | pages = 539-45 | month = Sep | year = 2011 | doi = 10.1111/j.1440-1827.2011.02711.x | PMID = 21884304 }}</ref>
*Traditionally thought of as a pediatric tumour... but cases in adults are reported.<ref name=pmid21884304>{{Cite journal  | last1 = Ishihara | first1 = A. | last2 = Yamashita | first2 = Y. | last3 = Takamori | first3 = H. | last4 = Kuroda | first4 = N. | title = Renal carcinoma with (6;11)(p21;q12) translocation: Report of an adult case. | journal = Pathol Int | volume = 61 | issue = 9 | pages = 539-45 | month = Sep | year = 2011 | doi = 10.1111/j.1440-1827.2011.02711.x | PMID = 21884304 }}</ref><ref name=pmid24877033>{{Cite journal  | last1 = Hora | first1 = M. | last2 = Urge | first2 = T. | last3 = Trávníček | first3 = I. | last4 = Ferda | first4 = J. | last5 = Chudáček | first5 = Z. | last6 = Vaněček | first6 = T. | last7 = Michal | first7 = M. | last8 = Petersson | first8 = F. | last9 = Kuroda | first9 = N. | title = MiT translocation renal cell carcinomas: two subgroups of tumours with translocations involving 6p21 [t (6; 11)] and Xp11.2 [t (X;1 or X or 17)]. | journal = Springerplus | volume = 3 | issue =  | pages = 245 | month =  | year = 2014 | doi = 10.1186/2193-1801-3-245 | PMID = 24877033 }}</ref>


==Microscopic==
==Microscopic==
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*Hyaline material between nests.
*Hyaline material between nests.
*Large cells with clear to eosinophilic cytoplasm.
*Large cells with clear to eosinophilic cytoplasm.
==IHC==
*HMB-45 +ve.<ref name=pmid24877033/>


==Molecular==
==Molecular==

Revision as of 06:53, 30 December 2014

Renal tumour with t(6;11) translocation, also t(6;11) renal cell carcinoma, is a rare kidney tumour seen primarily in children.

It also known as TFEB RCC.[1]

General

  • Very rare - approximately 2 dozen reported cases as of 2014.[1][2]
  • Lymph node metastases are common.
  • Traditionally thought of as a pediatric tumour... but cases in adults are reported.[3][1]

Microscopic

Features:

  • Hyaline material between nests.
  • Large cells with clear to eosinophilic cytoplasm.

IHC

Molecular

  • t(6;11)(p21;q12) Alpha/TFEB.[4]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Hora, M.; Urge, T.; Trávníček, I.; Ferda, J.; Chudáček, Z.; Vaněček, T.; Michal, M.; Petersson, F. et al. (2014). "MiT translocation renal cell carcinomas: two subgroups of tumours with translocations involving 6p21 [t (6; 11)] and Xp11.2 [t (X;1 or X or 17)].". Springerplus 3: 245. doi:10.1186/2193-1801-3-245. PMID 24877033.
  2. ↑ Argani, P.; Yonescu, R.; Morsberger, L.; Morris, K.; Netto, GJ.; Smith, N.; Gonzalez, N.; Illei, PB. et al. (Oct 2012). "Molecular confirmation of t(6;11)(p21;q12) renal cell carcinoma in archival paraffin-embedded material using a break-apart TFEB FISH assay expands its clinicopathologic spectrum.". Am J Surg Pathol 36 (10): 1516-26. doi:10.1097/PAS.0b013e3182613d8f. PMID 22892601.
  3. ↑ Ishihara, A.; Yamashita, Y.; Takamori, H.; Kuroda, N. (Sep 2011). "Renal carcinoma with (6;11)(p21;q12) translocation: Report of an adult case.". Pathol Int 61 (9): 539-45. doi:10.1111/j.1440-1827.2011.02711.x. PMID 21884304.
  4. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 281. ISBN 978-0781765275.
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