Difference between revisions of "Salivary glands"

Salivary glands (view source)

1,053 bytes added , 02:59, 12 January 2011

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 ==Salivary duct carcinoma==
-Needs work.
+===General===
+*Malignant counterpart of ''salivary duct adenoma''.
+*Male:female ~= 4:1.
+*Typically >50 years old.
+*Mostly in the parotid.
+===Microscopic===
+Features:
+*Architecture: sheets, nests, cords, cribriform, micropapillary.
+*Neoplastic cells line-up around cystic spaces "Roman bridges".
+*Nuclear atypia (variation in size, shape, staining).
+*Apocrine snouts - pseudopod-like/lollipop-like undulations of the cell membrane.
+*Decapitation secretions - apocrine snouts (membrane bound blobs of cytoplasm) that have separated from its mother cell.
+Image:
+*[http://www.webpathology.com/image.asp?case=122&n=2 Salivary duct carcinoma (webpathology.com)].
-*Malignant counterpart of ''salivary duct adenoma''.
+Notes:
+*Similar to ductal breast carcinoma.
+====Subtypes====
+*Conventional.
+*Mucinous - worse prognosis; opposite of what would one expect from the outcomes in [[breast cancer]].
+*Micropapillary - assoc. with a poor prognosis.
+*Sarcomatoid/spindle cell.
+===IHC===
+*LMWK, EMA, CK7, CK19 +ve.
+*p63 -ve.
+*Androgen receptor +ve.
+*BRST2 (GCDFP-15) +ve.
+*HER2 +ve ~21%; use of trastuzumab (Herceptin) not systematically studied.
+Curiosity:
+*PSA +/-.
+*PSAP +/-.
 ==Polymorphous low-grade adenocarcinoma==