Difference between revisions of "Oligoastrocytoma"
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'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected ''not'' to be a distinct entity.<ref name=pmid25143301>{{Cite journal | last1 = Sahm | first1 = F. | last2 = Reuss | first2 = D. | last3 = Koelsche | first3 = C. | last4 = Capper | first4 = D. | last5 = Schittenhelm | first5 = J. | last6 = Heim | first6 = S. | last7 = Jones | first7 = DT. | last8 = Pfister | first8 = SM. | last9 = Herold-Mende | first9 = C. | title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal = Acta Neuropathol | volume = 128 | issue = 4 | pages = 551-9 | month = Oct | year = 2014 | doi = 10.1007/s00401-014-1326-7 | PMID = 25143301 }}</ref> | '''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected '''not''' to be a distinct entity.<ref name=pmid25143301>{{Cite journal | last1 = Sahm | first1 = F. | last2 = Reuss | first2 = D. | last3 = Koelsche | first3 = C. | last4 = Capper | first4 = D. | last5 = Schittenhelm | first5 = J. | last6 = Heim | first6 = S. | last7 = Jones | first7 = DT. | last8 = Pfister | first8 = SM. | last9 = Herold-Mende | first9 = C. | title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal = Acta Neuropathol | volume = 128 | issue = 4 | pages = 551-9 | month = Oct | year = 2014 | doi = 10.1007/s00401-014-1326-7 | PMID = 25143301 }}</ref> | ||
==General== | ==General== | ||
Revision as of 07:52, 10 December 2014
Oligoastrocytoma is an uncommon neuropathology tumour that is suspected not to be a distinct entity.[1]
General
- Mixed tumour by definition.
- More sophisticated testing usually allows separation into oligodendroglioma or astrocytoma.[1]
Microscopic
Features:
- Astrocytoma-like and oligodendroglioma-like:
- Oligodendroglioma-like cells = round nucleus, peri-nuclear clearing.
- Astrocytoma-like cells = non-ovoid/elongated nucleus.
DDx:
IHC
- Oligodendroglioma-like cells: MAP-2 +ve (cytoplasm).
- Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).
Others:
- Ki-67 ~10%. (???)
- p53 - focally +ve. (???)
- IDH-1 +ve. (85%)
See also
References
- ↑ 1.0 1.1 Sahm, F.; Reuss, D.; Koelsche, C.; Capper, D.; Schittenhelm, J.; Heim, S.; Jones, DT.; Pfister, SM. et al. (Oct 2014). "Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma.". Acta Neuropathol 128 (4): 551-9. doi:10.1007/s00401-014-1326-7. PMID 25143301.