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Pilomyxoid astrocytoma (view source)
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'''Pilomyxoid astrocytoma''' is a [[neuropathology tumour]] related to [[pilocytic astrocytoma]]. | |||
===General=== | |||
Features:<ref name=Ref_PSNP86>{{Ref PSNP|86}}</ref> | |||
*A variant of ''pilocytic astrocytoma''. | |||
**Some have suggested it is a unique entity.<ref name=pmid16048293>{{cite journal |author=Komotar RJ, Mocco J, Jones JE, ''et al.'' |title=Pilomyxoid astrocytoma: diagnosis, prognosis, and management |journal=Neurosurg Focus |volume=18 |issue=6A |pages=E7 |year=2005 |month=June |pmid=16048293 |doi= |url=}}</ref> | |||
*Childhood or adolescence. | |||
===Gross=== | |||
Features:<ref name=Ref_PSNP86>{{Ref PSNP|86}}</ref> | |||
*Classically - hypothalamic location/suprasellar location; may involve the sella turcica.<ref name=pmid19766001>{{cite journal |author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A |title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent |journal=J Clin Neurosci |volume=16 |issue=12 |pages=1648–9 |year=2009 |month=December |pmid=19766001 |doi=10.1016/j.jocn.2009.01.035 |url=}}</ref> | |||
*Solid. | |||
*Well-circumscribed. | |||
===Microscopic=== | |||
Features:<ref name=Ref_PSNP86>{{Ref PSNP|86}}</ref> | |||
*Consists of small round/ovoid bland cells in a [[myxoid stroma]]. | |||
*Hair-like fibres ~ 1 micrometer. | |||
**Often difficult to appreciate on standard (H&E) histologic sections. | |||
*Usually angiocentric (surround blood vessel) - '''key feature'''. | |||
Notes:<ref name=Ref_PSNP86>{{Ref PSNP|86}}</ref> | |||
*Rosenthal fibres are absent - '''key negative'''. | |||
*Monophasic (unlike classical pilocytic astrocytomas) - '''key negative'''. | |||
*May rarely have eosinophilic granular bodies. | |||
<gallery> | |||
Image:Pilomyxoid Astrocytoma HE20x.jpg | Pilomyxoid astrocytoma. (WC/Marvin 101) | |||
</gallery> | |||
===Grading=== | |||
*''WHO Grade II'' by definition.<ref name=Ref_PSNP86>{{Ref PSNP|86}}</ref> | |||
==See also== | |||
*[[Neuropathology tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | |||