Difference between revisions of "Uterine tumours"

Jump to navigation Jump to search

Uterine tumours (view source)

Revision as of 02:27, 24 November 2014

3,713 bytes removed ,  02:27, 24 November 2014
→‎Adenosarcoma of the uterus: split out
Line 129: Line 129:
==Adenosarcoma of the uterus==
==Adenosarcoma of the uterus==
*[[AKA]] ''uterine adenocarcinoma''.  
*[[AKA]] ''uterine adenocarcinoma''.  
===General===
{{Main|Adenosarcoma of the uterus}}
Features:<ref name=pmid20179434>{{Cite journal  | last1 = McCluggage | first1 = WG. | title = Mullerian adenosarcoma of the female genital tract. | journal = Adv Anat Pathol | volume = 17 | issue = 2 | pages = 122-9 | month = Mar | year = 2010 | doi = 10.1097/PAP.0b013e3181cfe732 | PMID = 20179434 }}</ref>
*Uncommon.
*May prolapse through cervical os and thus present as [[cervical polyp]].
*Most commonly uterine corpus, occasionally cervix and ovary, rarely in the vagina, fallopian tube, peritoneal surfaces, intestine.
*Typically 30-40 years old.
 
Clinical:<ref name=pmid17506376>{{Cite journal  | last1 = Abu | first1 = J. | last2 = Ireland | first2 = D. | last3 = Brown | first3 = L. | title = Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. | journal = J Reprod Med | volume = 52 | issue = 4 | pages = 326-8 | month = Apr | year = 2007 | doi =  | PMID = 17506376 }}</ref>
*Most common presentations of Müllerian adenosarcoma (percentages based on series of 41 individuals<ref name=pmid9625851>{{Cite journal  | last1 = Verschraegen | first1 = CF. | last2 = Vasuratna | first2 = A. | last3 = Edwards | first3 = C. | last4 = Freedman | first4 = R. | last5 = Kudelka | first5 = AP. | last6 = Tornos | first6 = C. | last7 = Kavanagh | first7 = JJ. | title = Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience. | journal = Oncol Rep | volume = 5 | issue = 4 | pages = 939-44 | month =  | year =  | doi =  | PMID = 9625851 }}</ref>):
**Vaginal bleeding ~ 70%.
**Pelvic mass ~ 40%.
**Uterine polyp ~ 30%.
*Prognosis (based on series of ~500 individuals<ref name=pmid20688363>{{Cite journal  | last1 = Arend | first1 = R. | last2 = Bagaria | first2 = M. | last3 = Lewin | first3 = SN. | last4 = Sun | first4 = X. | last5 = Deutsch | first5 = I. | last6 = Burke | first6 = WM. | last7 = Herzog | first7 = TJ. | last8 = Wright | first8 = JD. | title = Long-term outcome and natural history of uterine adenosarcomas. | journal = Gynecol Oncol | volume = 119 | issue = 2 | pages = 305-8 | month = Nov | year = 2010 | doi = 10.1016/j.ygyno.2010.07.001 | PMID = 20688363 }}</ref>):
**Favourable outcome - most detected at an early stage.
***~80% five year survival for stage I tumours.
**Outcome better than [[uterine carcinosarcoma|carcinosarcoma]].
 
Treatment:
*TAH-BSO.
**Tumours are estrogen responsive.
*Chemotherapy (platin-based).<ref name=pmid9625851/>
 
===Microscopic===
Features:<ref name=Ref_PBoD1089>{{Ref PBoD|1089}}</ref><ref name=pmid20179434/>
*"Malignant stroma" - '''key feature'''.
**Stromal nuclear pleomorphism - usually low grade.
**WHO criteria: 2+ mitoses / 10 HPF -- definition suffers from [[HPFitis]].
***Mitotic rate criteria often ignored as mitotically inactive tumours metastasize.<ref name=pmid20179434/>
*Benign glands with an abnormal shape.
*"Cambium layer" = increased cellularity around the epithelial elements.<ref name=pmid20179434/><ref name=medilexicon_cambium/>
 
Notes:
*Tumour may vaguely resemble a [[phyllodes tumour]].<ref name=pmid20179434/>
*''Cambium layer'' - seen in: adenosarcoma, botryoid [[RMS]].<ref name=medilexicon_cambium>URL: [http://www.medilexicon.com/medicaldictionary.php?t=48297 http://www.medilexicon.com/medicaldictionary.php?t=48297]. Accessed on: 9 August 2011.</ref>
 
DDx:
*[[Benign endometrial polyp]].
*[[Uterine adenofibroma]].
 
====Images====
<gallery>
Image:Uterine_adenosarcoma_-_low_mag.jpg | Uterine adenosarcoma - low mag. (WC)
Image:Uterine_adenosarcoma_-_intermed_mag.jpg | Uterine adenosarcoma - intermed. mag. (WC)
Image:Uterine_adenosarcoma_-_high_mag.jpg | Uterine adenosarcoma - high mag. (WC)
</gallery>
 
===IHC===
*CD10 +ve.<ref name=pmid20179434/>
*ER +ve.
*PR +ve.


==Uterine leiomyosarcoma==
==Uterine leiomyosarcoma==
Michael
48,830

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/35138"

Navigation menu