Difference between revisions of "Myofibroma"
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'''Myofibroma''' is a soft tissue lesion in the group [[Fibroblastic/myofibroblastic_tumours|fibroblastic/myofibroblastic tumours]]. | |||
==General== | |||
*Benign. | |||
*Often < 2 years old; however, may be seen in adults. | |||
*Not common.<ref name=pmid20038894>{{Cite journal | last1 = Brasileiro | first1 = BF. | last2 = Martins-Filho | first2 = PR. | last3 = Piva | first3 = MR. | last4 = da Silva | first4 = LC. | last5 = Nonaka | first5 = CF. | last6 = Miguel | first6 = MC. | title = Myofibroma of the oral cavity. A rare spindle cell neoplasm. | journal = Med Oral Patol Oral Cir Bucal | volume = 15 | issue = 4 | pages = e596-600 | month = Jul | year = 2010 | doi = | PMID = 20038894 | url= http://www.medicinaoral.com/pubmed/medoralv15_i4_p596.pdf }}</ref> | |||
==Gross== | |||
*Classically (oral) locations: [[tongue]], buccal mucosa, lip.<ref name=pmid20038894/> | |||
==Microscopic== | |||
Features:<ref name=pmid20038894/> | |||
*Spindle cells with: | |||
**Tapering nuclei. | |||
**Eosinophilic cytoplasm. | |||
Note: | |||
*Features overlap with [[myopericytoma]].<ref name=pmid16394283>{{cite journal |author=Dray MS, McCarthy SW, Palmer AA, ''et al.'' |title=Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases |journal=J. Clin. Pathol. |volume=59 |issue=1 |pages=67–73 |year=2006 |month=January |pmid=16394283 |pmc=1860256 |doi=10.1136/jcp.2005.028704 |url= }}</ref> | |||
DDx: | |||
*[[Neurofibroma]]. | |||
*[[Leiomyoma]]. | |||
===Images=== | |||
www: | |||
*[http://casereports.bmj.com/content/2014/bcr-2014-203977/F5.large.jpg Myofibroma (bmj.com)].<ref name=pmid25178888>{{Cite journal | last1 = Rai | first1 = B. | last2 = Ludusan | first2 = E. | last3 = McGovern | first3 = B. | last4 = Sharif | first4 = F. | title = Mandibular swelling in a 5-year-old child--mandibular myofibroma. | journal = BMJ Case Rep | volume = 2014 | issue = | pages = | month = | year = 2014 | doi = 10.1136/bcr-2014-203977 | PMID = 25178888 }}</ref> | |||
==IHC== | |||
Features:<ref name=pmid20038894/> | |||
*Vimentin +ve. | |||
*SMA +ve. | |||
*S-100 -ve, | |||
==See also== | |||
*[[Fibroblastic/myofibroblastic tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Fibroblastic/myofibroblastic tumours]] | |||
Latest revision as of 00:08, 16 November 2014
Myofibroma is a soft tissue lesion in the group fibroblastic/myofibroblastic tumours.
General
- Benign.
- Often < 2 years old; however, may be seen in adults.
- Not common.[1]
Gross
Microscopic
Features:[1]
- Spindle cells with:
- Tapering nuclei.
- Eosinophilic cytoplasm.
Note:
- Features overlap with myopericytoma.[2]
DDx:
Images
www:
IHC
Features:[1]
- Vimentin +ve.
- SMA +ve.
- S-100 -ve,
See also
References
- ↑ 1.0 1.1 1.2 1.3 Brasileiro, BF.; Martins-Filho, PR.; Piva, MR.; da Silva, LC.; Nonaka, CF.; Miguel, MC. (Jul 2010). "Myofibroma of the oral cavity. A rare spindle cell neoplasm.". Med Oral Patol Oral Cir Bucal 15 (4): e596-600. PMID 20038894. http://www.medicinaoral.com/pubmed/medoralv15_i4_p596.pdf.
- ↑ Dray MS, McCarthy SW, Palmer AA, et al. (January 2006). "Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases". J. Clin. Pathol. 59 (1): 67–73. doi:10.1136/jcp.2005.028704. PMC 1860256. PMID 16394283. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860256/.
- ↑ Rai, B.; Ludusan, E.; McGovern, B.; Sharif, F. (2014). "Mandibular swelling in a 5-year-old child--mandibular myofibroma.". BMJ Case Rep 2014. doi:10.1136/bcr-2014-203977. PMID 25178888.