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Difference between revisions of "Clear cell adenocarcinoma of the urethra"
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Clear cell adenocarcinoma of the urethra (view source)
Revision as of 20:59, 13 November 2014
, 20:59, 13 November 2014→Microscopic
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==General== | ==General== | ||
*Predominantly in women.<ref name=pmid24389164>{{Cite journal | last1 = Mehra | first1 = R. | last2 = Vats | first2 = P. | last3 = Kalyana-Sundaram | first3 = S. | last4 = Udager | first4 = AM. | last5 = Roh | first5 = M. | last6 = Alva | first6 = A. | last7 = Pan | first7 = J. | last8 = Lonigro | first8 = RJ. | last9 = Siddiqui | first9 = J. | title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. | journal = Am J Pathol | volume = 184 | issue = 3 | pages = 584-91 | month = Mar | year = 2014 | doi = 10.1016/j.ajpath.2013.11.023 | PMID = 24389164 }}</ref> | *Predominantly in women.<ref name=pmid24389164>{{Cite journal | last1 = Mehra | first1 = R. | last2 = Vats | first2 = P. | last3 = Kalyana-Sundaram | first3 = S. | last4 = Udager | first4 = AM. | last5 = Roh | first5 = M. | last6 = Alva | first6 = A. | last7 = Pan | first7 = J. | last8 = Lonigro | first8 = RJ. | last9 = Siddiqui | first9 = J. | title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. | journal = Am J Pathol | volume = 184 | issue = 3 | pages = 584-91 | month = Mar | year = 2014 | doi = 10.1016/j.ajpath.2013.11.023 | PMID = 24389164 }}</ref> | ||
* | |||
Pathogenesis not well understood - may arise from: | |||
*Muellerian rests or [[urothelium]].<ref name=pmid24389164/> | |||
*Shed [[kidney tumours|kidney cells]].<ref name=pmid23307189/> | |||
*[[Nephrogenic adenoma]] - malignant transformation.<ref name=pmid24389164/> | |||
==Microscopic== | ==Microscopic== | ||
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DDx: | DDx: | ||
*[[Nephrogenic adenoma]]<ref name=pmid23307189/> - also has hobnailing. | *[[Nephrogenic adenoma]]<ref name=pmid23307189/><ref name=pmid21496868>{{Cite journal | last1 = Brimo | first1 = F. | last2 = Herawi | first2 = M. | last3 = Sharma | first3 = R. | last4 = Netto | first4 = GJ. | last5 = Epstein | first5 = JI. | last6 = Illei | first6 = PB. | title = Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis. | journal = Hum Pathol | volume = 42 | issue = 11 | pages = 1613-9 | month = Nov | year = 2011 | doi = 10.1016/j.humpath.2011.01.007 | PMID = 21496868 }}</ref> - also has hobnailing, not mitotically active, no necrosis, no or mild [[nuclear atypia]]. | ||
*[[Clear cell renal cell carcinoma]]. | *[[Clear cell renal cell carcinoma]]. | ||
*[[Clear cell adenocarcinoma]] of the gynecologic tract. | *[[Clear cell adenocarcinoma]] of the gynecologic tract. | ||
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www: | www: | ||
*[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3936309_gr1.jpg CCA of the urethra (nih.gov)].<ref name=pmid24389164/> | *[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3936309_gr1.jpg CCA of the urethra (nih.gov)].<ref name=pmid24389164/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479785/figure/F3/ CCA of the urethra (nih.gov)].<ref>{{Cite journal | last1 = Han | first1 = JY. | last2 = Kim | first2 = KH. | last3 = Kim | first3 = L. | last4 = Choi | first4 = SJ. | last5 = Park | first5 = IS. | last6 = Kim | first6 = JM. | last7 = Chu | first7 = YC. | last8 = Yoon | first8 = SM. | title = Cytologic findings of clear cell adenocarcinoma of the urethra: a case report. | journal = Korean J Pathol | volume = 46 | issue = 2 | pages = 210-4 | month = Apr | year = 2012 | doi = 10.4132/KoreanJPathol.2012.46.2.210 | PMID = 23110004 }}</ref> | |||
==IHC== | ==IHC== | ||
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*[[PSA]] -ve. | *[[PSA]] -ve. | ||
*p16 -ve. | *p16 -ve. | ||
*Ki-67 ~ 47/200 on average cells. | |||
**5.5/200 cells on average in nephrogenic adenoma.<ref name=pmid9865832>{{Cite journal | last1 = Gilcrease | first1 = MZ. | last2 = Delgado | first2 = R. | last3 = Vuitch | first3 = F. | last4 = Albores-Saavedra | first4 = J. | title = Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison. | journal = Hum Pathol | volume = 29 | issue = 12 | pages = 1451-6 | month = Dec | year = 1998 | doi = | PMID = 9865832 }}</ref> | |||
==See also== | ==See also== | ||