Difference between revisions of "Clear cell adenocarcinoma of the urethra"
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*similar to [[clear cell adenocarcinoma]] of the gynecologic tract - see ''[[clear cell carcinoma of the uterine cervix]]''. | *Described as morphologically similar to [[clear cell adenocarcinoma]] of the gynecologic tract<ref name=pmid23307189>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Tavora | first2 = F. | title = Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems. | journal = Virchows Arch | volume = 462 | issue = 2 | pages = 193-201 | month = Feb | year = 2013 | doi = 10.1007/s00428-012-1363-3 | PMID = 23307189 }}</ref> - see ''[[clear cell carcinoma of the uterine cervix]]''. | ||
DDx: | DDx: | ||
*[[Nephrogenic adenoma]] - also has hobnailing. | |||
*[[Clear cell tumours]]. | *[[Clear cell tumours]]. | ||
**[[Clear cell adenocarcinoma]] of the gynecologic tract. | **[[Clear cell adenocarcinoma]] of the gynecologic tract. | ||
Revision as of 18:59, 12 November 2014
Clear cell adenocarcinoma of the urethra, also primary urethral clear cell adenocarcinoma, is a very rare malignant tumour of the urethra.
General
- Predominantly in women.[1]
Microscopic
Features:[1]
- Clear cells - at least focally.
- Hobnailing - classic feature.
Note:
- Described as morphologically similar to clear cell adenocarcinoma of the gynecologic tract[2] - see clear cell carcinoma of the uterine cervix.
DDx:
- Nephrogenic adenoma - also has hobnailing.
- Clear cell tumours.
- Clear cell adenocarcinoma of the gynecologic tract.
- Clear cell renal cell carcinoma.
- Others.
Images
www:
IHC
Features:
- PAX8 +ve.
- CK7 +ve.
Others:
- CK20 -ve.
- ER -ve.
- PR -ve.
- p53 -ve.
- p63 -ve.
See also
References
- ↑ 1.0 1.1 1.2 Mehra, R.; Vats, P.; Kalyana-Sundaram, S.; Udager, AM.; Roh, M.; Alva, A.; Pan, J.; Lonigro, RJ. et al. (Mar 2014). "Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.". Am J Pathol 184 (3): 584-91. doi:10.1016/j.ajpath.2013.11.023. PMID 24389164.
- ↑ Alexiev, BA.; Tavora, F. (Feb 2013). "Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.". Virchows Arch 462 (2): 193-201. doi:10.1007/s00428-012-1363-3. PMID 23307189.