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Difference between revisions of "Angiosarcoma"
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| IHC = CD31 +ve, FLI-1 +ve, CD34 +ve, HHV-8 -ve | | IHC = CD31 +ve, FLI-1 +ve, CD34 +ve, HHV-8 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = +/-MYC amplification | ||
| IF = | | IF = | ||
| Gross = red lesion{{fact}} | | Gross = red lesion{{fact}} | ||
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*D2-40 +ve/-ve.<ref name=pmid11950918>{{Cite journal | last1 = Kahn | first1 = HJ. | last2 = Bailey | first2 = D. | last3 = Marks | first3 = A. | title = Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. | journal = Mod Pathol | volume = 15 | issue = 4 | pages = 434-40 | month = Apr | year = 2002 | doi = 10.1038/modpathol.3880543 | PMID = 11950918 | URL = http://www.nature.com/modpathol/journal/v15/n4/full/3880543a.html }}</ref> | *D2-40 +ve/-ve.<ref name=pmid11950918>{{Cite journal | last1 = Kahn | first1 = HJ. | last2 = Bailey | first2 = D. | last3 = Marks | first3 = A. | title = Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. | journal = Mod Pathol | volume = 15 | issue = 4 | pages = 434-40 | month = Apr | year = 2002 | doi = 10.1038/modpathol.3880543 | PMID = 11950918 | URL = http://www.nature.com/modpathol/journal/v15/n4/full/3880543a.html }}</ref> | ||
*HHV-8 -ve. | *HHV-8 -ve. | ||
==Molecular== | |||
*Amplification of MYC<ref name=pmid25374893>{{Cite journal | last1 = Kurisetty | first1 = V. | last2 = Bryan | first2 = BA. | title = Aberrations in Angiogenic Signaling and MYC Amplifications are Distinguishing Features of Angiosarcoma. | journal = Angiol Open Access | volume = 1 | issue = | pages = | month = Apr | year = 2013 | doi = 10.4172/2329-9495.1000102 | PMID = 25374893 }}</ref> - esp. in secondary angiosarcoma.<ref name=pmid24983371>{{Cite journal | last1 = Styring | first1 = E. | last2 = Seinen | first2 = J. | last3 = Dominguez-Valentin | first3 = M. | last4 = Domanski | first4 = HA. | last5 = Jönsson | first5 = M. | last6 = von Steyern | first6 = FV. | last7 = Hoekstra | first7 = HJ. | last8 = Suurmeijer | first8 = AJ. | last9 = Nilbert | first9 = M. | title = Key roles for MYC, KIT and RET signaling in secondary angiosarcomas. | journal = Br J Cancer | volume = 111 | issue = 2 | pages = 407-12 | month = Jul | year = 2014 | doi = 10.1038/bjc.2014.359 | PMID = 24983371 }}</ref> | |||
==See also== | ==See also== | ||