Difference between revisions of "Juxtaglomerular cell tumour"
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==IHC== | ==IHC== | ||
Features:<ref name= | Features: | ||
*CD34 +ve.<ref name=pmid21871063/> | |||
*Vimentin +ve. | |||
*Actin +ve. | *Actin +ve. | ||
*Cytokeratin -ve. | *Cytokeratin -ve.<ref name=pmid21191395>{{Cite journal | last1 = Chao | first1 = CT. | last2 = Chang | first2 = FC. | last3 = Wu | first3 = VC. | last4 = Chen | first4 = JC. | title = Reninoma. | journal = Kidney Int | volume = 79 | issue = 2 | pages = 260 | month = Jan | year = 2011 | doi = 10.1038/ki.2010.445 | PMID = 21191395 }}</ref> | ||
*HMB-45 -ve. | *HMB-45 -ve.<ref name=pmid21191395/> | ||
Others:<ref name=pmid21871063/> | |||
*CD31 -ve. | |||
*Desmin -ve. | |||
*S-100 -ve. | |||
*Chromogranin -ve. | |||
*Synaptophysin -ve. | |||
*NSE -ve. | |||
==EM== | ==EM== | ||
Revision as of 04:32, 9 November 2014
Juxtaglomerular cell tumour, abbreviated JCT, is a rare kidney tumour.
It is also known as juxtaglomerular tumour and reninoma.[1]
General
- Rare.
- Etiology: increased renin.
Clinical:[1]
- Hypertension.
- Increased aldosterone.
- Causes hypokalemia.
- Increased plasma renin.
Microscopic
Features:[2]
- Polygonal cells.
- Abundant granular, eosinophilic cytoplasm.[3]
- Perinuclear halo.
DDx:
- Chromophobe renal cell carcinoma, eosinophilic variant.
Images
Stains
Cytoplasmic granules.[3]
- PAS +ve.
- PASD +ve.
IHC
Features:
Others:[4]
- CD31 -ve.
- Desmin -ve.
- S-100 -ve.
- Chromogranin -ve.
- Synaptophysin -ve.
- NSE -ve.
EM
Features:
- Vesicles - contain renin.[5]
See also
References
- ↑ 1.0 1.1 Wong, L.; Hsu, TH.; Perlroth, MG.; Hofmann, LV.; Haynes, CM.; Katznelson, L. (Feb 2008). "Reninoma: case report and literature review.". J Hypertens 26 (2): 368-73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
- ↑ 2.0 2.1 2.2 2.3 Chao, CT.; Chang, FC.; Wu, VC.; Chen, JC. (Jan 2011). "Reninoma.". Kidney Int 79 (2): 260. doi:10.1038/ki.2010.445. PMID 21191395.
- ↑ 3.0 3.1 Hanna, W.; Tepperman, B.; Logan, AG.; Robinette, MA.; Colapinto, R.; Phillips, MJ. (Apr 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension.". Can Med Assoc J 120 (8): 957-9. PMID PMC = 1819229 436071 PMC = 1819229.
- ↑ 4.0 4.1 4.2 4.3 Kuroda, N.; Gotoda, H.; Ohe, C.; Mikami, S.; Inoue, K.; Nagashima, Y.; Petersson, F.; Alvarado-Cabrero, I. et al. (2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect.". Diagn Pathol 6: 80. doi:10.1186/1746-1596-6-80. PMID 21871063.
- ↑ URL: http://path.upmc.edu/cases/case29/micro.html. Accessed on: 18 December 2011.