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Difference between revisions of "Sinus histiocytosis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sinus histiocytosis -- intermed mag.jpg | |||
| Width = | |||
| Caption = Sinus histiocytosis. [[H&E stain]]. | |||
| Micro = sinuses distended with histiocytes without atypia | |||
| Subtypes = | |||
| LMDDx = [[Rosai-Dorfman disease]], [[dermatopathic lymphadenopathy]], [[lymph node metastasis]] | |||
| Stains = | |||
| IHC = CD68 +ve, S-100 -ve, pankeratin -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]] - see ''[[lymph node pathology]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = variable | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other causes of lymphadenopathy esp. [[lymphoma]], [[lymph node metastasis]] | |||
}} | |||
'''Sinus histiocytosis''', abbreviated '''SH''', is a common finding in [[lymph nodes]]. | '''Sinus histiocytosis''', abbreviated '''SH''', is a common finding in [[lymph nodes]]. | ||
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Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref> | Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref> | ||
*Sinuses distended with histiocytes - '''key feature'''. | *Sinuses distended with histiocytes - '''key feature'''. | ||
**Histocytes: abundant foamy cytoplasm, +/- | **Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]] and/or [[yellow bodies]]. | ||
*[[Plasma cell]]s increased. | *[[Plasma cell]]s increased. | ||
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*[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus. | *[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus. | ||
*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment. | *[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment. | ||
*[[Lymph node metastasis]] - usually not difficult if one compares | *[[Lymph node metastasis]] - usually not difficult to exclude, esp. if one compares the germinal center macrophages and the primary tumour. | ||
===Images=== | ===Images=== | ||
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*CD68 +ve. | *CD68 +ve. | ||
*S-100 -ve. | *S-100 -ve. | ||
*Pankeratin -ve. | |||
**Used to excluded metastatic carcinoma. | |||
==Sign out== | ==Sign out== | ||