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Difference between revisions of "Fibrous dysplasia"
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==Molecular== | ==Molecular== | ||
Postzygotic (somatic) activating mutations of the GNAS1 gene 10, which encodes the α-subunit of the stimulatory G-protein Gs<ref>{{Cite journal | last1 = Weinstein | first1 = LS. | last2 = Shenker | first2 = A. | last3 = Gejman | first3 = PV. | last4 = Merino | first4 = MJ. | last5 = Friedman | first5 = E. | last6 = Spiegel | first6 = AM. | title = Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. | journal = N Engl J Med | volume = 325 | issue = 24 | pages = 1688-95 | month = Dec | year = 1991 | doi = 10.1056/NEJM199112123252403 | PMID = 1944469 }}</ref> | *Postzygotic (somatic) activating mutations of the GNAS1 gene 10, which encodes the α-subunit of the stimulatory G-protein Gs<ref>{{Cite journal | last1 = Weinstein | first1 = LS. | last2 = Shenker | first2 = A. | last3 = Gejman | first3 = PV. | last4 = Merino | first4 = MJ. | last5 = Friedman | first5 = E. | last6 = Spiegel | first6 = AM. | title = Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. | journal = N Engl J Med | volume = 325 | issue = 24 | pages = 1688-95 | month = Dec | year = 1991 | doi = 10.1056/NEJM199112123252403 | PMID = 1944469 }}</ref> | ||
*Both mono and polyostatic cases. | |||
*Causative molecular lesion of McCune-Albright and Mazzabraud syndrome | |||
==See also== | ==See also== | ||
*[[Bone]]. | *[[Bone]]. | ||