Difference between revisions of "Lhermitte-Duclos disease"

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*+/-Microcalcifications.
*+/-Microcalcifications.


Images:
===Images===
<gallery>
Image:Dysplastic gangliocytoma lhermitte duclos.jpg | LDD. (WC/Jensflorian)
</gallery>
www:
*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].



Revision as of 14:51, 17 October 2014

Lhermitte-Duclos_disease, abbreviated LDD, is a rare neuropathology.

It is also known as dysplastic cerebellar gangliocytoma[1] and dysplastic gangliocytoma of the cerebellum.

General

Microscopic

Features:[3]

  • The outer (molecular) layer has increased cellularity.
  • Purkinje cells absent.[1]
  • Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - key feature.
  • +/-Microcalcifications.

Images

www:

See also

References

  1. 1.0 1.1 Yağci-Küpeli, B.; Oguz, KK.; Bilen, MA.; Yalçin, B.; Akalan, N.; Büyükpamukçu, M. (Mar 2010). "An unusual cause of posterior fossa mass: Lhermitte-Duclos disease.". J Neurol Sci 290 (1-2): 138-41. doi:10.1016/j.jns.2009.12.010. PMID 20060133.
  2. Online 'Mendelian Inheritance in Man' (OMIM) 158350
  3. URL: http://path.upmc.edu/cases/case472.html. Accessed on: 21 January 2012.