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Difference between revisions of "Neuropathology tumours"
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→Common brain tumours in a table
m (→Gliosarcoma) |
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| Line 73: | Line 73: | ||
|Normal tissue | |Normal tissue | ||
|regular spacing, no atypia | |regular spacing, no atypia | ||
|small lesion? | |small lesion? / deep lesion? | ||
|variable | |variable | ||
|missed lesion? | |missed lesion? | ||
|nil | |nil | ||
|[http://commons.wikimedia.org/wiki/File:Grey_matter_and_white_matter_-_very_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Grey_matter_and_white_matter_-_high_mag.jpg] | |[http://commons.wikimedia.org/wiki/File:Grey_matter_and_white_matter_-_very_high_mag.jpg very high mag.], [http://commons.wikimedia.org/wiki/File:Grey_matter_and_white_matter_-_high_mag.jpg high mag.] | ||
|- | |- | ||
|Reactive astrocytes | |Reactive astrocytes | ||
|astrocytes with well-demarcated eosinophilic cytoplasm, regular spacing, no atypia | |astrocytes with well-demarcated eosinophilic cytoplasm, regular spacing, no atypia | ||
|small lesion? / deep lesion? | |||
|variable | |||
|missed lesion / close to a lesion; non-specific pathologic process - need more tissue | |||
|nil | |nil | ||
|[http://commons.wikimedia.org/wiki/File:Reactive_astrocytes_-_lfb_-_high_mag.jpg high mag.] | |||
|[http://commons.wikimedia.org/wiki/File:Reactive_astrocytes_-_lfb_-_high_mag.jpg] | |||
|- | |- | ||
|Astrocytoma | |Astrocytoma (grade II or worse) | ||
|glial processes (on smear), nuclear atypia (size var. ~3x, irreg. nuc. membrane, hyperchromasia) | |glial processes (esp. on smear), nuclear atypia (size var. ~3x, irreg. nuc. membrane, hyperchromasia), no Rosenthal fibres | ||
|enhancing, usu. supratentorial, usu. white matter | |often enhancing (suggests high grade), usu. supratentorial, usu. white matter | ||
|usu. old, occ. young | |usu. old, occ. young | ||
|very common, esp. glioblastoma | |very common, esp. glioblastoma | ||
|IDH-1+/- | |IDH-1+/-, GFAP+ | ||
|[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg] | |[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg high mag.], [http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg very high mag.] | ||
|- | |- | ||
|Metastasis | |Metastasis | ||
| Line 100: | Line 100: | ||
|usu. old | |usu. old | ||
|often suspected to have metastatic disease | |often suspected to have metastatic disease | ||
|TTF-1, CK7, CK20 | |TTF-1, CK7, CK20, BRST-2 | ||
|[http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg], [http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg] | |[http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg very low mag.], [http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg high mag.] | ||
|- | |- | ||
|Meningioma | |Meningioma | ||
| Line 109: | Line 109: | ||
|may be diagnosed on smear, DDx: choroid plexus, schwannoma | |may be diagnosed on smear, DDx: choroid plexus, schwannoma | ||
|EMA, PR, Ki-67 | |EMA, PR, Ki-67 | ||
|[http://commons.wikimedia.org/wiki/File:Meningioma_intermed_mag.jpg] | |[http://commons.wikimedia.org/wiki/File:Meningioma_intermed_mag.jpg intermed. mag.] | ||
|- | |- | ||
|Schwannoma | |Schwannoma | ||
| Line 117: | Line 117: | ||
|need frozen section to Dx | |need frozen section to Dx | ||
|S100 | |S100 | ||
|[http://commons.wikimedia.org/wiki/File:Peripheral_schwannoma_Antoni_type_A_(1).JPG] | |[http://commons.wikimedia.org/wiki/File:Peripheral_schwannoma_Antoni_type_A_(1).JPG intermed. mag.] | ||
|} | |} | ||