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Difference between revisions of "Embryonal carcinoma"
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==IHC== | ==IHC== | ||
[[ISUP]] consensus paper by Ulbright ''et al.'':<ref name=pmid24832161>{{cite journal |author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR |title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference |journal=Am. J. Surg. Pathol. |volume=38 |issue=8 |pages=e50–9 |year=2014 |month=August |pmid=24832161 |doi=10.1097/PAS.0000000000000233 |url=}}</ref> | |||
*OCT4 +ve. | |||
**Choriocarcinoma, yolk sac tumour and spermatocytic seminoma all -ve. | |||
*CD30 +ve. | |||
**-ve in [[seminoma]]. | |||
*CD117 -ve.<ref name=pmid17277761/> | |||
**+ve in [[seminoma]]. | |||
Additional notes: | |||
*AE1/AE3 +ve. | *AE1/AE3 +ve. | ||
*OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal | last1 = Iczkowski | first1 = KA. | last2 = Butler | first2 = SL. | last3 = Shanks | first3 = JH. | last4 = Hossain | first4 = D. | last5 = Schall | first5 = A. | last6 = Meiers | first6 = I. | last7 = Zhou | first7 = M. | last8 = Torkko | first8 = KC. | last9 = Kim | first9 = SJ. | title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. | journal = Hum Pathol | volume = 39 | issue = 2 | pages = 275-81 | month = Feb | year = 2008 | doi = 10.1016/j.humpath.2007.07.002 | PMID = 18045648 }}</ref> | *OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal | last1 = Iczkowski | first1 = KA. | last2 = Butler | first2 = SL. | last3 = Shanks | first3 = JH. | last4 = Hossain | first4 = D. | last5 = Schall | first5 = A. | last6 = Meiers | first6 = I. | last7 = Zhou | first7 = M. | last8 = Torkko | first8 = KC. | last9 = Kim | first9 = SJ. | title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. | journal = Hum Pathol | volume = 39 | issue = 2 | pages = 275-81 | month = Feb | year = 2008 | doi = 10.1016/j.humpath.2007.07.002 | PMID = 18045648 }}</ref> | ||
*D2-40 -ve.<ref name=pmid18045648/> | *D2-40 -ve.<ref name=pmid18045648/> | ||
**Iczkowski ''et al.'' suggest it is useful for discriminating from [[seminoma]]. This is somewhat disputed by Lau ''et al.''<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | **Iczkowski ''et al.'' suggest it is useful for discriminating from [[seminoma]]. This is somewhat disputed by Lau ''et al.''<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | ||
*PLAP +ve.<ref name=pmid6209917>{{Cite journal | last1 = Jacobsen | first1 = GK. | last2 = Nørgaard-Pedersen | first2 = B. | title = Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study. | journal = Acta Pathol Microbiol Immunol Scand A | volume = 92 | issue = 5 | pages = 323-9 | month = Sep | year = 1984 | doi = | PMID = 6209917 }}</ref> | *PLAP +ve.<ref name=pmid6209917>{{Cite journal | last1 = Jacobsen | first1 = GK. | last2 = Nørgaard-Pedersen | first2 = B. | title = Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study. | journal = Acta Pathol Microbiol Immunol Scand A | volume = 92 | issue = 5 | pages = 323-9 | month = Sep | year = 1984 | doi = | PMID = 6209917 }}</ref> | ||