Difference between revisions of "Exaggerated placental site"
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'''Exaggerated placental site''', abbreviated '''EPS''', is an uncommon benign pathology that is a | |||
[[gestational trophoblastic disease]]. | |||
It was previously known as '''syncytial endometritis'''.<ref>URL: [http://www.webpathology.com/image.asp?case=565&n=7 http://www.webpathology.com/image.asp?case=565&n=7]. Accessed on: 22 May 2014.</ref><ref name=pmid7014653>{{cite journal |author=Heyderman E, Gibbons AR, Rosen SW |title=Immunoperoxidase localisation of human placental lactogen: a marker for the placental origin of the giant cells in 'syncytial endometritis' of pregnancy |journal=J. Clin. Pathol. |volume=34 |issue=3 |pages=303–7 |year=1981 |month=March |pmid=7014653 |pmc=1146481 |doi= |url=}}</ref> | |||
==General== | |||
*Benign. | |||
Definition: | |||
*"Increased number" of implantation-site [[Intermediate trophoblast|intermediate trophoblastic cells]]. | |||
Note: | |||
*Used to go by a terrible old term: ''syncytial endometritis'':<ref name=ouhsc_kfung>URL: [http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf]. Accessed on: 15 August 2011.</ref> | |||
**Not syncytial -- mostly. | |||
**Not inflammatory. | |||
==Microscopic== | |||
Features:<ref name=ouhsc_kfung/> | |||
*Intermediate trophoblast: | |||
**Abundant (eosinophilic) cytoplasm. | |||
*Usu. adjacent to: | |||
**[[Chorionic villi]]. | |||
**Decidua - endometrial stromal cells with a nucleus central, eosinphilic cytoplasm, well-defined cell borders. | |||
*No mitotic activity. | |||
*Ectatic blood vessels. | |||
DDx: | |||
*[[PSTT]]. | |||
===Image=== | |||
*[http://www.webpathology.com/image.asp?case=565&n=7 EPS (webpathology.com)]. | |||
==IHC== | |||
*MIB1 ~0%. | |||
**Used to differentiate from [[PSTT]]. | |||
*hPL +ve.<ref name=pmid7014653>{{cite journal |author=Heyderman E, Gibbons AR, Rosen SW |title=Immunoperoxidase localisation of human placental lactogen: a marker for the placental origin of the giant cells in 'syncytial endometritis' of pregnancy |journal=J. Clin. Pathol. |volume=34 |issue=3 |pages=303–7 |year=1981 |month=March |pmid=7014653 |pmc=1146481 |doi= |url=}}</ref><ref name=pmid15498215/> | |||
*CK18 +ve.<ref name=pmid15498215>{{cite journal |author=Shen DH, Liao XY, Liu YL, Wang H, Yu YZ |title=[Clinicopathological study of intermediate trophoblastic non-tumor lesions: exaggerated placental site and placental site nodule] |language=Chinese |journal=Zhonghua Bing Li Xue Za Zhi |volume=33 |issue=5 |pages=441–4 |year=2004 |month=October |pmid=15498215 |doi= |url=}}</ref> | |||
==See also== | |||
*[[Gestational trophoblastic disease]]. | |||
*[[Endometritis]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Gestational trophoblastic disease]] | |||
[[Category:Diagnosis]] | |||
Latest revision as of 11:12, 7 July 2014
Exaggerated placental site, abbreviated EPS, is an uncommon benign pathology that is a gestational trophoblastic disease.
It was previously known as syncytial endometritis.[1][2]
General
- Benign.
Definition:
- "Increased number" of implantation-site intermediate trophoblastic cells.
Note:
- Used to go by a terrible old term: syncytial endometritis:[3]
- Not syncytial -- mostly.
- Not inflammatory.
Microscopic
Features:[3]
- Intermediate trophoblast:
- Abundant (eosinophilic) cytoplasm.
- Usu. adjacent to:
- Chorionic villi.
- Decidua - endometrial stromal cells with a nucleus central, eosinphilic cytoplasm, well-defined cell borders.
- No mitotic activity.
- Ectatic blood vessels.
DDx:
- PSTT.
Image
IHC
See also
References
- ↑ URL: http://www.webpathology.com/image.asp?case=565&n=7. Accessed on: 22 May 2014.
- ↑ 2.0 2.1 Heyderman E, Gibbons AR, Rosen SW (March 1981). "Immunoperoxidase localisation of human placental lactogen: a marker for the placental origin of the giant cells in 'syncytial endometritis' of pregnancy". J. Clin. Pathol. 34 (3): 303–7. PMC 1146481. PMID 7014653. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1146481/.
- ↑ 3.0 3.1 URL: http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf. Accessed on: 15 August 2011.
- ↑ 4.0 4.1 Shen DH, Liao XY, Liu YL, Wang H, Yu YZ (October 2004). "[Clinicopathological study of intermediate trophoblastic non-tumor lesions: exaggerated placental site and placental site nodule]" (in Chinese). Zhonghua Bing Li Xue Za Zhi 33 (5): 441–4. PMID 15498215.