Difference between revisions of "Fibrous hamartoma of infancy"

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'''Fibrous hamartoma''' is an uncommon lesion of infants.
'''Fibrous hamartoma''' is an uncommon lesion usually seen in infancy.


==General==
==General==
*Uncommon.
*Uncommon.
*Infants. {{fact}}
*Infants and young children.<ref name=pmid24525510>{{Cite journal  | last1 = Saab | first1 = ST. | last2 = McClain | first2 = CM. | last3 = Coffin | first3 = CM. | title = Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. | journal = Am J Surg Pathol | volume = 38 | issue = 3 | pages = 394-401 | month = Mar | year = 2014 | doi = 10.1097/PAS.0000000000000104 | PMID = 24525510 }}</ref>
 
==Gross==
*Typical location: lower back, gluteal region or [[scrotum]].<ref name=pmid22066102/>
 
==Microscopic==
==Microscopic==
Features:
Features:<ref name=pmid24525510/>
*Fibrous tissue.
*Adipose tissue.
*Adipose tissue.
*Nerve-like tissue.
*Mesenchymal tissue - nerve-like.
*???
*+/-Pseudoangiomatous pattern.


DDx:
DDx:
*[[Neurofibroma]].
*[[Neurofibroma]].
*[[GCT of the tendon shealth]].
*[[GCT of the tendon shealth]].
===Images===
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657246/figure/F1/ FH (nih.gov)].<ref name=pmid23716836>{{Cite journal  | last1 = F-Eire | first1 = P. | last2 = Fojon | first2 = JG. | title = Cutaneous changes in fibrous hamartoma of infancy. | journal = Indian J Dermatol | volume = 58 | issue = 2 | pages = 160 | month = Mar | year = 2013 | doi = 10.4103/0019-5154.108089 | PMID = 23716836 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204559/figure/F1/ FH (nih.gov)].<ref name=pmid22066102>{{Cite journal  | last1 = Kang | first1 = G. | last2 = Suh | first2 = YL. | last3 = Han | first3 = J. | last4 = Kwon | first4 = GY. | last5 = Lee | first5 = SK. | last6 = Seo | first6 = JM. | title = Fibrous hamartoma of infancy: an experience of a single institute. | journal = J Korean Surg Soc | volume = 81 | issue = 1 | pages = 61-5 | month = Jul | year = 2011 | doi = 10.4174/jkss.2011.81.1.61 | PMID = 22066102 }}</ref>


==IHC==
==IHC==
*S-100 -ve.  
Features:<ref name=pmid24525510/>
*S-100 -ve.
**Adipose tissue +ve.
*SMA +ve (fibrous tissue).
*CD34 +ve (fibrous tissue, immature mesenchymal tissue, pseudoangiomatous foci).
 
==See also==
*[[Pediatric pathology]].
*[[Dermatopathology]].


==References==
{{reflist|1}}


[[Category:Dermatopathology]]
[[Category:Dermatopathology]]

Revision as of 02:42, 22 June 2014

Fibrous hamartoma is an uncommon lesion usually seen in infancy.

General

  • Uncommon.
  • Infants and young children.[1]

Gross

  • Typical location: lower back, gluteal region or scrotum.[2]

Microscopic

Features:[1]

  • Fibrous tissue.
  • Adipose tissue.
  • Mesenchymal tissue - nerve-like.
  • +/-Pseudoangiomatous pattern.

DDx:

Images

IHC

Features:[1]

  • S-100 -ve.
    • Adipose tissue +ve.
  • SMA +ve (fibrous tissue).
  • CD34 +ve (fibrous tissue, immature mesenchymal tissue, pseudoangiomatous foci).

See also

References

  1. ↑ 1.0 1.1 1.2 Saab, ST.; McClain, CM.; Coffin, CM. (Mar 2014). "Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases.". Am J Surg Pathol 38 (3): 394-401. doi:10.1097/PAS.0000000000000104. PMID 24525510.
  2. ↑ 2.0 2.1 Kang, G.; Suh, YL.; Han, J.; Kwon, GY.; Lee, SK.; Seo, JM. (Jul 2011). "Fibrous hamartoma of infancy: an experience of a single institute.". J Korean Surg Soc 81 (1): 61-5. doi:10.4174/jkss.2011.81.1.61. PMID 22066102.
  3. ↑ F-Eire, P.; Fojon, JG. (Mar 2013). "Cutaneous changes in fibrous hamartoma of infancy.". Indian J Dermatol 58 (2): 160. doi:10.4103/0019-5154.108089. PMID 23716836.
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