49,260
edits
Difference between revisions of "Trichoblastoma"
Jump to navigation
Jump to search
→IHC
(split out) |
(→IHC) |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Trichoepithelioma - 2 - high mag.jpg | |||
| Width = | |||
| Caption = Trichoepithelioma. [[H&E stain]]. | |||
| Micro = typically well-circumscribed cell nest in the superficial dermis, surrounding by a fibrous stroma, basaloid cells - usu. with [[peripheral palisading]] +/-surround keratin-filled cysts, fibroblasts-like cell aggregate, similar to a follicular papillae (papillary-mesenchymal body) | |||
| Subtypes = desmoplastic | |||
| LMDDx = [[basal cell carcinoma]], [[dermal cylindroma]], [[trichofolliculoma]], [[sebaceous carcinoma]], [[microcystic adnexal carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[skin]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Trichoblastoma''', also known as '''trichoepithelioma''', is an uncommon [[dermatologic neoplasms|skin tumour]]. | '''Trichoblastoma''', also known as '''trichoepithelioma''', is an uncommon [[dermatologic neoplasms|skin tumour]]. | ||
| Line 28: | Line 57: | ||
*[[Trichofolliculoma]]. | *[[Trichofolliculoma]]. | ||
*[[Sebaceous carcinoma]], well-differentiated - has some cells with clear vacuolated cytoplasm. | *[[Sebaceous carcinoma]], well-differentiated - has some cells with clear vacuolated cytoplasm. | ||
*[[Microcystic adnexal carcinoma]] - esp. desmoplastic trichoblastoma. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image:Trichoepithelioma - low mag.jpg | Trichoepithelioma - low mag. (WC/Nephron) | ||
Image: | Image:Trichoepithelioma - intermed mag.jpg | Trichoepithelioma - intermed. mag. (WC/Nephron) | ||
Image:Trichoepithelioma - high mag.jpg | Trichoepithelioma - high mag. (WC/Nephron) | |||
Image:Trichoepithelioma - very high mag.jpg | Trichoepithelioma - very high mag. (WC/Nephron) | |||
</gallery> | |||
<gallery> | |||
Image: Trichoepithelioma - 2 - intermed mag.jpg | Trichoepithelioma - intermed. mag. (WC) | |||
Image: Trichoepithelioma - 2 - high mag.jpg | Trichoepithelioma - high mag. (WC) | |||
Image: Trichoepithelioma - 2 - very high mag.jpg | Trichoepithelioma - very high mag. (WC) | |||
</gallery> | </gallery> | ||
www: | www: | ||
| Line 38: | Line 75: | ||
*[http://skinpathologyatlas.com/tumors/hair/images/trichofollic-20x-pal.jpg Papillary-mesenchymal body (skinpathologyatlas.com)].<ref>URL: [http://skinpathologyatlas.com/tumors/hair/trichofollic.htm http://skinpathologyatlas.com/tumors/hair/trichofollic.htm]. Accessed on: 22 August 2012.</ref> | *[http://skinpathologyatlas.com/tumors/hair/images/trichofollic-20x-pal.jpg Papillary-mesenchymal body (skinpathologyatlas.com)].<ref>URL: [http://skinpathologyatlas.com/tumors/hair/trichofollic.htm http://skinpathologyatlas.com/tumors/hair/trichofollic.htm]. Accessed on: 22 August 2012.</ref> | ||
*[http://www.dermnetnz.org/common/image.php?path=/pathology/img/t/trichoepitheliomafigure3.jpg Trichoepithelioma (dermnetnz.org)]. | *[http://www.dermnetnz.org/common/image.php?path=/pathology/img/t/trichoepitheliomafigure3.jpg Trichoepithelioma (dermnetnz.org)]. | ||
==IHC== | |||
Features:<ref>{{cite journal |author=Córdoba A, Guerrero D, Larrinaga B, Iglesias ME, Arrechea MA, Yanguas JI |title=Bcl-2 and CD10 expression in the differential diagnosis of trichoblastoma, basal cell carcinoma, and basal cell carcinoma with follicular differentiation |journal=Int. J. Dermatol. |volume=48 |issue=7 |pages=713–7 |year=2009 |month=July |pmid=19570076 |doi=10.1111/j.1365-4632.2009.04076.x |url=}}</ref> | |||
*CD10 +ve -- peritumoural. | |||
**Also reported in epithelium.<ref name=pmid15618927>{{cite journal |author=Yada K, Kashima K, Daa T, Kitano S, Fujiwara S, Yokoyama S |title=Expression of CD10 in basal cell carcinoma |journal=Am J Dermatopathol |volume=26 |issue=6 |pages=463–71 |year=2004 |month=December |pmid=15618927 |doi= |url=}}</ref> | |||
**Epithelial staining in BCC. | |||
*BCL2. (???) | |||
==Sign out== | ==Sign out== | ||
| Line 51: | Line 95: | ||
The lesion is completely excised in the plane of section. | The lesion is completely excised in the plane of section. | ||
==See also== | ==See also== | ||
*[[Dermatologic neoplasms]]. | *[[Dermatologic neoplasms]]. | ||