Difference between revisions of "Granulocytic sarcoma"
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Cluster of atypical small blue cells in [[soft tissue lesions|soft tissue]]. | *Cluster of atypical small blue cells in [[soft tissue lesions|soft tissue]] with scant cytoplasm. | ||
DDx: | |||
* | *[[Small cell carcinoma]] | ||
*Large cell lymphomas ([[DLBCL]], [[ALCL]]). | |||
*Other [[small round cell tumour]]s. | |||
===Images=== | ===Images=== |
Revision as of 12:51, 21 May 2014
Granulocytic sarcoma | |
---|---|
Diagnosis in short | |
Chloroma. H&E stain. | |
| |
Synonyms | extramedullary leukemia, myeloid sarcoma and chloroma, myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, myelosarcoma |
| |
LM | atypical small blue cells ~2x resting lymphocyte, infiltrative |
LM DDx | small round cell tumours |
Site | soft tissue lesion |
| |
Prevalence | rare |
Clin. DDx | other soft tissue lesions |
Treatment | see acute myeloid leukemia |
Granulocytic sarcoma is an uncommon malignant soft tissue lesion that really represents a hematologic malignancy; it is a soft tissue manifestation of acute myeloid leukemia. It is not a sarcoma.
Numerous other terms refer to this including extramedullary leukemia,[1] myeloid sarcoma and chloroma.
Less common terms include:[2] myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, and myelosarcoma.
General
- Soft tissue manifestation of acute myeloid leukemia.[2]
Microscopic
Features:
- Cluster of atypical small blue cells in soft tissue with scant cytoplasm.
DDx:
- Small cell carcinoma
- Large cell lymphomas (DLBCL, ALCL).
- Other small round cell tumours.
Images
www:
- Granulocytic sarcoma - several crappy images (upmc.edu).
- Myeloid sarcoma - several images (upmc.edu).
Sign out
- It is prudent to mention acute myeloid leukemia somewhere in the report to ensure the appropriate referral is made.
See also
References
- ↑ Bakst, RL.; Tallman, MS.; Douer, D.; Yahalom, J. (Oct 2011). "How I treat extramedullary acute myeloid leukemia.". Blood 118 (14): 3785-93. doi:10.1182/blood-2011-04-347229. PMID 21795742.
- ↑ 2.0 2.1 Eom, KS.; Kim, TY. (Mar 2011). "Intraparenchymal myeloid sarcoma and subsequent spinal myeloid sarcoma for acute myeloblastic leukemia.". J Korean Neurosurg Soc 49 (3): 171-4. doi:10.3340/jkns.2011.49.3.171. PMC 3085814. PMID 21556238. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085814/.