Difference between revisions of "Immune thrombocytopenic purpura"
Jump to navigation
Jump to search
| Line 2: | Line 2: | ||
==General== | ==General== | ||
Presentation: | |||
*Bleeding - usually.<ref name=pmid23714309>{{cite journal |author=Kistangari G, McCrae KR |title=Immune thrombocytopenia |journal=Hematol. Oncol. Clin. North Am. |volume=27 |issue=3 |pages=495–520 |year=2013 |month=June |pmid=23714309 |doi=10.1016/j.hoc.2013.03.001 |url=}}</ref> | |||
Treatment: | |||
*Usually treated with corticosteroids.<ref name=pmid23714309/> | |||
**Possibly retuximab.<ref>{{Cite journal | last1 = Zhang | first1 = C. | last2 = Liu | first2 = HF. | last3 = Chen | first3 = XH. | last4 = Gao | first4 = L. | last5 = Gao | first5 = L. | last6 = Liu | first6 = Y. | last7 = Kong | first7 = PY. | last8 = Sun | first8 = AH. | last9 = Zhang | first9 = X. | title = Is splenectomy necessary for immune thrombocytopenic purpura? The role of rituximab in patients with corticosteroid resistance in a single-center experience. | journal = Clin Ther | volume = 36 | issue = 3 | pages = 385-8 | month = Mar | year = 2014 | doi = 10.1016/j.clinthera.2014.01.017 | PMID = 24594069 }}</ref> | |||
*Refractory cases get a splenectomy. | |||
Prevalence: | |||
*Uncommon. | *Uncommon. | ||
===Classification=== | |||
*Primary. | |||
*Secondary. | |||
**Viral. | |||
**Bacterial - possibly [[Helicobacter pylori]].<ref>{{cite journal |author=Kuwana M |title=Helicobacter pylori-associated immune thrombocytopenia: clinical features and pathogenic mechanisms |journal=World J. Gastroenterol. |volume=20 |issue=3 |pages=714–23 |year=2014 |month=January |pmid=24574745 |pmc=3921481 |doi=10.3748/wjg.v20.i3.714 |url=}}</ref> | |||
==Gross== | ==Gross== | ||
Revision as of 03:44, 6 May 2014
Immune thrombocytopenic purpura, abbreviated ITP, is a rare condition.
General
Presentation:
- Bleeding - usually.[1]
Treatment:
Prevalence:
- Uncommon.
Classification
- Primary.
- Secondary.
- Viral.
- Bacterial - possibly Helicobacter pylori.[3]
Gross
Features:[4]
- Typically ~ 100 grams.
- +/-Prominent white nodules (AKA Malpighian corpuscles) - uncommon.
Microscopic
Features:[4]
- Germinal centres in white pulp (~55% of cases)
- Classically described as "proliferative".
- Neutrophils in the red pulp (~67% of cases).
- Macrophages in the red pulp (~25% of cases). †
Notes:
- Changes not dependent on titre of antiplatelet antibodies.[4]
- † May be a finding associated with treatment.[4]
- The classic changes are proliferation of lymphoid germinal centres and red pulp PMNs.
Images
See also
References
- ↑ 1.0 1.1 Kistangari G, McCrae KR (June 2013). "Immune thrombocytopenia". Hematol. Oncol. Clin. North Am. 27 (3): 495–520. doi:10.1016/j.hoc.2013.03.001. PMID 23714309.
- ↑ Zhang, C.; Liu, HF.; Chen, XH.; Gao, L.; Gao, L.; Liu, Y.; Kong, PY.; Sun, AH. et al. (Mar 2014). "Is splenectomy necessary for immune thrombocytopenic purpura? The role of rituximab in patients with corticosteroid resistance in a single-center experience.". Clin Ther 36 (3): 385-8. doi:10.1016/j.clinthera.2014.01.017. PMID 24594069.
- ↑ Kuwana M (January 2014). "Helicobacter pylori-associated immune thrombocytopenia: clinical features and pathogenic mechanisms". World J. Gastroenterol. 20 (3): 714–23. doi:10.3748/wjg.v20.i3.714. PMC 3921481. PMID 24574745. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921481/.
- ↑ 4.0 4.1 4.2 4.3 Hayes MM, Jacobs P, Wood L, Dent DM (September 1985). "Splenic pathology in immune thrombocytopenia". J. Clin. Pathol. 38 (9): 985–8. PMC 499346. PMID 4044880. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC499346/.